NUP133
Summary: The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nucleoporin 133 | MIM:607613 | Ensembl:ENSG00000069248 | HGNC:HGNC:18016 | PA31847 | 1q42.13 |
Gene Categories:
TRANSPORTERGO terms in NUP133
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017056 | structural constituent of nuclear pore |
| MF | IDA | GO:0017056 | structural constituent of nuclear pore |
| CC | IBA | GO:0000777 | condensed chromosome kinetochore |
| CC | IDA | GO:0000777 | condensed chromosome kinetochore |
| CC | IDA | GO:0000940 | condensed chromosome outer kinetochore |
| CC | TAS | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005643 | nuclear pore |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0031080 | nuclear pore outer ring |
| CC | IDA | GO:0031080 | nuclear pore outer ring |
| CC | NAS | GO:0031080 | nuclear pore outer ring |
| CC | IDA | GO:0031965 | nuclear membrane |
| BP | IBA | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery |
| BP | IBA | GO:0006325 | chromatin organization |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006405 | RNA export from nucleus |
| BP | IDA | GO:0006406 | mRNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | IBA | GO:0006606 | protein import into nucleus |
| BP | IMP | GO:0006999 | nuclear pore organization |
| BP | TAS | GO:0016032 | viral process |
| BP | IEA | GO:0021915 | neural tube development |
| BP | IEA | GO:0022008 | neurogenesis |
| BP | IBA | GO:0031081 | nuclear pore distribution |
| BP | IEA | GO:0048339 | paraxial mesoderm development |
| BP | IEA | GO:0061053 | somite development |
Gene expression in normal tissue: NUP133
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUP133
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159227 | Transport of the SLBP independent Mature mRNA |
| reactome | R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA |
| reactome | R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript |
| reactome | R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| reactome | R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165054 | Rev-mediated nuclear export of HIV RNA |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-168325 | Viral Messenger RNA Synthesis |
| reactome | R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery |
| reactome | R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| reactome | R-HSA-176033 | Interactions of Vpr with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-180910 | Vpr-mediated nuclear import of PICs |
| reactome | R-HSA-191859 | snRNP Assembly |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194441 | Metabolism of non-coding RNA |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3232142 | SUMOylation of ubiquitinylation proteins |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085377 | SUMOylation of SUMOylation proteins |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4570464 | SUMOylation of RNA binding proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6784531 | tRNA processing in the nucleus |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD298 | L-685458 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD872 | BRD7137 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUP133
CLASSFICATION
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