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CXCL9

Summary: This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
C-X-C motif chemokine ligand 9	MIM:601704	Ensembl:ENSG00000138755	HGNC:HGNC:7098	PA35495	4q21.1

Gene Categories:

DRUGGABLE GENOME CELL SURFACE EXTERNAL SIDE OF PLASMA MEMBRANE

GO terms in CXCL9

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0006935	chemotaxis
BP	TAS	GO:0006952	defense response
BP	IBA	GO:0006954	inflammatory response
BP	IBA	GO:0006955	immune response
BP	TAS	GO:0006968	cellular defense response
BP	TAS	GO:0007165	signal transduction
BP	TAS	GO:0007186	G-protein coupled receptor signaling pathway
BP	TAS	GO:0007267	cell-cell signaling
BP	IEA	GO:0010469	regulation of signaling receptor activity
BP	IBA	GO:0030593	neutrophil chemotaxis
BP	IBA	GO:0030595	leukocyte chemotaxis
BP	IDA	GO:0042127	regulation of cell proliferation
BP	IDA	GO:0043950	positive regulation of cAMP-mediated signaling
BP	IEA	GO:0045663	positive regulation of myoblast differentiation
BP	IDA	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
BP	IEA	GO:0051607	defense response to virus
BP	IBA	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
BP	IBA	GO:0070098	chemokine-mediated signaling pathway
BP	IBA	GO:0071222	cellular response to lipopolysaccharide
BP	IEA	GO:1901741	positive regulation of myoblast fusion
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	IEA	GO:0009897	external side of plasma membrane
MF	TAS	GO:0005125	cytokine activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0008009	chemokine activity
MF	IDA	GO:0008009	chemokine activity
MF	IBA	GO:0045236	CXCR chemokine receptor binding
MF	IDA	GO:0048248	CXCR3 chemokine receptor binding

Gene expression in normal tissue: CXCL9

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CXCL9

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-373076	Class A/1 (Rhodopsin-like receptors)
reactome	R-HSA-375276	Peptide ligand-binding receptors
reactome	R-HSA-380108	Chemokine receptors bind chemokines
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-418594	G alpha (i) signalling events
reactome	R-HSA-500792	GPCR ligand binding
pid	cxcr3pathway	CXCR3-mediated signaling events
pid	il23pathway	IL23-mediated signaling events
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04620	Toll-like receptor signaling pathway - Homo sapiens (human)
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP2328	Allograft Rejection
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP619	Type II interferon signaling (IFNG)
wikipathways	WP75	Toll-like Receptor Signaling Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD138	PX 12	3
iGMDRD474	Avrainvillamide	2
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD434	BMS-536924	3
iGMDRD105	Triptolide	3
iGMDRD289	Parthenolide	3
iGMDRD705	Nakiterpiosin	2
iGMDRD267	Oligomycin A	3
iGMDRD286	Nsc 632839	2
iGMDRD188	Piperlongumine	3
iGMDRD100	Zebularine	3
iGMDRD562	Navitoclax	2
iGMDRD330	BRD4132	1
iGMDRD599	Salermide	6
iGMDRD85	Ursolic acid	4
iGMDRD61	Kinetin riboside	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXCL9

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.