EPHB1


Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor B1MIM:600600Ensembl:ENSG00000154928HGNC:HGNC:3392PA278243q22.2

GO terms in EPHB1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFEXPGO:0004713protein tyrosine kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFIDAGO:0005005transmembrane-ephrin receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008046axon guidance receptor activity
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIEAGO:0044877protein-containing complex binding
CCTASGO:0005576extracellular region
CCIBAGO:0005737cytoplasm
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIEAGO:0030424axon
CCIEAGO:0030425dendrite
CCIDAGO:0031901early endosome membrane
CCIEAGO:0032433filopodium tip
CCIBAGO:0043005neuron projection
CCIBAGO:0043235receptor complex
CCIEAGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome
BPIDAGO:0001525angiogenesis
BPIEAGO:0001771immunological synapse formation
BPIBAGO:0007275multicellular organism development
BPISSGO:0007411axon guidance
BPIBAGO:0009968negative regulation of signal transduction
BPISSGO:0014719skeletal muscle satellite cell activation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021631optic nerve morphogenesis
BPISSGO:0021952central nervous system projection neuron axonogenesis
BPISSGO:0022008neurogenesis
BPISSGO:0030010establishment of cell polarity
BPIBAGO:0030154cell differentiation
BPISSGO:0031290retinal ganglion cell axon guidance
BPIDAGO:0031589cell-substrate adhesion
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPIDAGO:0046328regulation of JNK cascade
BPIDAGO:0046777protein autophosphorylation
BPIDAGO:0048013ephrin receptor signaling pathway
BPTASGO:0048013ephrin receptor signaling pathway
BPIEAGO:0048593camera-type eye morphogenesis
BPISSGO:0050965detection of temperature stimulus involved in sensory perception of pain
BPISSGO:0051965positive regulation of synapse assembly
BPIDAGO:0060326cell chemotaxis
BPISSGO:0060996dendritic spine development
BPISSGO:0060997dendritic spine morphogenesis
BPISSGO:0061351neural precursor cell proliferation
BPIDAGO:0070372regulation of ERK1 and ERK2 cascade
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:1901214regulation of neuron death
BPISSGO:1902723negative regulation of skeletal muscle satellite cell proliferation
BPISSGO:1902725negative regulation of satellite cell differentiation

Gene expression in normal tissue: EPHB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHB1


DatabasePathway IDPathway Des.
pidephbfwdpathwayEPHB forward signaling
pidephrinbrevpathwayEphrin B reverse signaling
kegghsa04360Axon guidance - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD387CHIR-990212
iGMDRD420Leucascandrolide A2
iGMDRD1008SR-II-138A1
iGMDRD670ML 2103
iGMDRD144NSC953975
iGMDRD446LY 21832402
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD152179324-69-71
iGMDRD394BX-7951
iGMDRD280CYTOCHALASIN B2
iGMDRD474Avrainvillamide1
iGMDRD8024-methylfasudil1
iGMDRD318PAC-12
iGMDRD30917AAG1
iGMDRD506Fedratinib8
iGMDRD577BIX012944
iGMDRD398Sepantronium2
iGMDRD780PP-301
iGMDRD562Navitoclax1
iGMDRD369TGX-1152
iGMDRD60Quinoclamine2
iGMDRD47ZM3363723
iGMDRD583LDN 1931892
iGMDRD57Chloropentafluorobenzene1
iGMDRD698Neratinib1
iGMDRD177Teniposide3
iGMDRD103SN-386
iGMDRD137Indisulam3
iGMDRD158NSC1415405
iGMDRD286Nsc 6328393
iGMDRD871BRD63682
iGMDRD872BRD71372
iGMDRD662JQ-13
iGMDRD505Pevonedistat2
iGMDRD42Vorinostat2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHB1

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