EPHB1
Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor B1 | MIM:600600 | Ensembl:ENSG00000154928 | HGNC:HGNC:3392 | PA27824 | 3q22.2 |
GO terms in EPHB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IDA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008046 | axon guidance receptor activity |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | IDA | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0032433 | filopodium tip |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IEA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001771 | immunological synapse formation |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007411 | axon guidance |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | ISS | GO:0014719 | skeletal muscle satellite cell activation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021631 | optic nerve morphogenesis |
| BP | ISS | GO:0021952 | central nervous system projection neuron axonogenesis |
| BP | ISS | GO:0022008 | neurogenesis |
| BP | ISS | GO:0030010 | establishment of cell polarity |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0031290 | retinal ganglion cell axon guidance |
| BP | IDA | GO:0031589 | cell-substrate adhesion |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0046328 | regulation of JNK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0048593 | camera-type eye morphogenesis |
| BP | ISS | GO:0050965 | detection of temperature stimulus involved in sensory perception of pain |
| BP | ISS | GO:0051965 | positive regulation of synapse assembly |
| BP | IDA | GO:0060326 | cell chemotaxis |
| BP | ISS | GO:0060996 | dendritic spine development |
| BP | ISS | GO:0060997 | dendritic spine morphogenesis |
| BP | ISS | GO:0061351 | neural precursor cell proliferation |
| BP | IDA | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:1901214 | regulation of neuron death |
| BP | ISS | GO:1902723 | negative regulation of skeletal muscle satellite cell proliferation |
| BP | ISS | GO:1902725 | negative regulation of satellite cell differentiation |
Gene expression in normal tissue: EPHB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD47 | ZM336372 | 3 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD42 | Vorinostat | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHB1
CLASSFICATION
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