LMO2
Summary: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:180385 Ensembl IDEnsembl:ENSG00000135363 HGNC IDHGNC:HGNC:6642 PHARMGKB IDPA30408 Map Location11p13 | |||||
GO terms in LMO2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IDA | GO:0042789 | mRNA transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0097067 | cellular response to thyroid hormone stimulus |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| CC | TAS | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: LMO2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LMO2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LMO2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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