LMO2


Summary: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
LIM domain only 2MIM:180385Ensembl:ENSG00000135363HGNC:HGNC:6642PA3040811p13

GO terms in LMO2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007275multicellular organism development
BPIDAGO:0042789mRNA transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0097067cellular response to thyroid hormone stimulus
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
CCTASGO:0005654nucleoplasm
CCIDAGO:0005667transcription factor complex
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIPIGO:0001102RNA polymerase II activating transcription factor binding
MFIDAGO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0043425bHLH transcription factor binding
MFIEAGO:0046872metal ion binding
MFIPIGO:0048037cofactor binding
MFIDAGO:0070888E-box binding

Gene expression in normal tissue: LMO2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LMO2


DatabasePathway IDPathway Des.
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib2
iGMDRD307Manumycin A1
iGMDRD772BRD47701
iGMDRD150RITA2
iGMDRD523Cyanoquinoline, 112
iGMDRD494Neopeltolide3
iGMDRD781Sirolimus5
iGMDRD341Triacsin c1
iGMDRD446LY 21832401
iGMDRD142NSC748593
iGMDRD61Kinetin riboside1
iGMDRD297Austocystin D2
iGMDRD123Isoevodiamine3
iGMDRD634SCHEMBL260804112
iGMDRD513BML-2593
iGMDRD474Avrainvillamide2
iGMDRD8024-methylfasudil1
iGMDRD289Parthenolide3
iGMDRD782DC-45-A21
iGMDRD434BMS-5369242
iGMDRD318PAC-11
iGMDRD870BRD636101
iGMDRD187BRD98763
iGMDRD188Piperlongumine1
iGMDRD286Nsc 6328392
iGMDRD100Zebularine1
iGMDRD414MST-3123
iGMDRD882CIL413
iGMDRD886Compound 1541A2
iGMDRD60Quinoclamine1
iGMDRD268Cerulenin1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LMO2

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