LMO2
Summary: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIM domain only 2 | MIM:180385 | Ensembl:ENSG00000135363 | HGNC:HGNC:6642 | PA30408 | 11p13 |
GO terms in LMO2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IDA | GO:0042789 | mRNA transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0097067 | cellular response to thyroid hormone stimulus |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IPI | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IDA | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | IDA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0043425 | bHLH transcription factor binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IPI | GO:0048037 | cofactor binding |
| MF | IDA | GO:0070888 | E-box binding |
Gene expression in normal tissue: LMO2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LMO2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD142 | NSC74859 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD634 | SCHEMBL2608041 | 12 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD268 | Cerulenin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LMO2
CLASSFICATION
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