NR1H3
Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor subfamily 1 group H member 3 | MIM:602423 | Ensembl:ENSG00000025434 | HGNC:HGNC:7966 | PA31751 | 11p11.2 |
GO terms in NR1H3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IBA | GO:0090575 | RNA polymerase II transcription factor complex |
| CC | IDA | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IBA | GO:0006629 | lipid metabolic process |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IC | GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| BP | IMP | GO:0010867 | positive regulation of triglyceride biosynthetic process |
| BP | IDA | GO:0010870 | positive regulation of receptor biosynthetic process |
| BP | IDA | GO:0010875 | positive regulation of cholesterol efflux |
| BP | IMP | GO:0010875 | positive regulation of cholesterol efflux |
| BP | IMP | GO:0010887 | negative regulation of cholesterol storage |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030522 | intracellular receptor signaling pathway |
| BP | IMP | GO:0032270 | positive regulation of cellular protein metabolic process |
| BP | IMP | GO:0032369 | negative regulation of lipid transport |
| BP | IDA | GO:0032376 | positive regulation of cholesterol transport |
| BP | IDA | GO:0032570 | response to progesterone |
| BP | IBA | GO:0033993 | response to lipid |
| BP | IDA | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway |
| BP | IBA | GO:0042632 | cholesterol homeostasis |
| BP | IDA | GO:0042632 | cholesterol homeostasis |
| BP | ISS | GO:0042632 | cholesterol homeostasis |
| BP | TAS | GO:0042752 | regulation of circadian rhythm |
| BP | ISS | GO:0043031 | negative regulation of macrophage activation |
| BP | IMP | GO:0043277 | apoptotic cell clearance |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IMP | GO:0045723 | positive regulation of fatty acid biosynthetic process |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048550 | negative regulation of pinocytosis |
| BP | IBA | GO:0050728 | negative regulation of inflammatory response |
| BP | ISS | GO:0050728 | negative regulation of inflammatory response |
| BP | IMP | GO:0051006 | positive regulation of lipoprotein lipase activity |
| BP | IBA | GO:0055088 | lipid homeostasis |
| BP | ISS | GO:0055088 | lipid homeostasis |
| BP | ISS | GO:0055092 | sterol homeostasis |
| BP | NAS | GO:0060336 | negative regulation of interferon-gamma-mediated signaling pathway |
| BP | ISS | GO:0070328 | triglyceride homeostasis |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | ISS | GO:0090188 | negative regulation of pancreatic juice secretion |
| BP | ISS | GO:0090341 | negative regulation of secretion of lysosomal enzymes |
| BP | IDA | GO:2000325 | regulation of nuclear receptor transcription coactivator activity |
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0004879 | nuclear receptor activity |
| MF | TAS | GO:0004879 | nuclear receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0008289 | lipid binding |
| MF | TAS | GO:0015485 | cholesterol binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0032810 | sterol response element binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IBA | GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Gene expression in normal tissue: NR1H3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NR1H3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8866427 | VLDLR internalisation and degradation |
| reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP2011 | SREBF and miR33 in cholesterol and lipid homeostasis |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2874 | Liver X Receptor Pathway |
| wikipathways | WP2878 | PPAR Alpha Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP4011 | Steatosis AOP |
| wikipathways | WP4149 | White fat cell differentiation |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD512 | nutlin 3 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NR1H3
CLASSFICATION
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