NR1H3

Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear receptor subfamily 1 group H member 3
OMIM IDMIM:602423
Ensembl IDEnsembl:ENSG00000025434
HGNC IDHGNC:HGNC:7966
PHARMGKB IDPA31751
Map Location11p11.2

GO terms in NR1H3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0000790 nuclear chromatin
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0043235 receptor complex
CC IBA GO:0090575 RNA polymerase II transcription factor complex
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Gene expression in normal tissue: NR1H3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 14undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 43LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 11

Gene-drug pathway distribution

Pathways in NR1H3


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Database
Pathway ID
Pathway Des.
biocarta pparapathway mechanism of gene regulation by peroxisome proliferators via ppara
reactome R-HSA-1430728 Metabolism
reactome R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
reactome R-HSA-1989781 PPARA activates gene expression
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-2990846 SUMOylation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD60 Quinoclamine 2
iGMDRD886 Compound 1541A 2
iGMDRD300 Tozasertib 2
iGMDRD322 FK 866 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR1H3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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