NTSR1
Summary: Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurotensin receptor 1 | MIM:162651 | Ensembl:ENSG00000101188 | HGNC:HGNC:8039 | PA31821 | 20q13.33 |
GO terms in NTSR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004930 | G-protein coupled receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016492 | G-protein coupled neurotensin receptor activity |
| MF | IMP | GO:0016492 | G-protein coupled neurotensin receptor activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0047485 | protein N-terminus binding |
| BP | IEA | GO:0001659 | temperature homeostasis |
| BP | IEA | GO:0003085 | negative regulation of systemic arterial blood pressure |
| BP | IEA | GO:0003254 | regulation of membrane depolarization |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007218 | neuropeptide signaling pathway |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0007612 | learning |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | IEA | GO:0014049 | positive regulation of glutamate secretion |
| BP | IEA | GO:0014054 | positive regulation of gamma-aminobutyric acid secretion |
| BP | IEA | GO:0033993 | response to lipid |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043576 | regulation of respiratory gaseous exchange |
| BP | IEA | GO:0050965 | detection of temperature stimulus involved in sensory perception of pain |
| BP | IEA | GO:0051280 | negative regulation of release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0051930 | regulation of sensory perception of pain |
| BP | IEA | GO:0060732 | positive regulation of inositol phosphate biosynthetic process |
| BP | IEA | GO:0070779 | D-aspartate import across plasma membrane |
| BP | IEA | GO:0071545 | inositol phosphate catabolic process |
| BP | IEA | GO:0090238 | positive regulation of arachidonic acid secretion |
| BP | IEA | GO:0097151 | positive regulation of inhibitory postsynaptic potential |
| BP | IEA | GO:0098712 | L-glutamate import across plasma membrane |
| BP | IEA | GO:0098900 | regulation of action potential |
| BP | IEA | GO:2001259 | positive regulation of cation channel activity |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IMP | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009898 | cytoplasmic side of plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0032280 | symmetric synapse |
| CC | IEA | GO:0043195 | terminal bouton |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | IEA | GO:0043198 | dendritic shaft |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IDA | GO:0045121 | membrane raft |
Gene expression in normal tissue: NTSR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTSR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTSR1
CLASSFICATION
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