HORMAD1
Summary: This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| HORMA domain containing 1 | MIM:609824 | Ensembl:ENSG00000143452 | HGNC:HGNC:25245 | PA134930374 | 1q21.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in HORMAD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001824 | blastocyst development |
| BP | ISS | GO:0007130 | synaptonemal complex assembly |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | ISS | GO:0042138 | meiotic DNA double-strand break formation |
| BP | ISS | GO:0048477 | oogenesis |
| BP | ISS | GO:0051177 | meiotic sister chromatid cohesion |
| BP | ISS | GO:0051321 | meiotic cell cycle |
| BP | ISS | GO:0051598 | meiotic recombination checkpoint |
| BP | ISS | GO:0060629 | regulation of homologous chromosome segregation |
| CC | IEA | GO:0000795 | synaptonemal complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005694 | chromosome |
Gene expression in normal tissue: HORMAD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HORMAD1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD562 | Navitoclax | 9 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 9 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD137 | Indisulam | 8 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD150 | RITA | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD79 | Gemcitabine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HORMAD1
CLASSFICATION
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