NTRK3


Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
neurotrophic receptor tyrosine kinase 3MIM:191316Ensembl:ENSG00000140538HGNC:HGNC:8033PA3181915q25.3

GO terms in NTRK3


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000187activation of MAPK activity
BPIEAGO:0001764neuron migration
BPIDAGO:0001933negative regulation of protein phosphorylation
BPTASGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007275multicellular organism development
BPIMPGO:0007507heart development
BPIEAGO:0007623circadian rhythm
BPIDAGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0010628positive regulation of gene expression
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0019056modulation by virus of host transcription
BPIBAGO:0030154cell differentiation
BPIDAGO:0030335positive regulation of cell migration
BPIDAGO:0032148activation of protein kinase B activity
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIBAGO:0033674positive regulation of kinase activity
BPIEAGO:0038179neurotrophin signaling pathway
BPIEAGO:0042490mechanoreceptor differentiation
BPIEAGO:0043065positive regulation of apoptotic process
BPIBAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0045471response to ethanol
BPIEAGO:0046777protein autophosphorylation
BPIEAGO:0048013ephrin receptor signaling pathway
BPIEAGO:0048665neuron fate specification
BPIEAGO:0048678response to axon injury
BPIEAGO:0048691positive regulation of axon extension involved in regeneration
BPIEAGO:0048712negative regulation of astrocyte differentiation
BPIDAGO:0050927positive regulation of positive chemotaxis
BPIEAGO:0051412response to corticosterone
BPIEAGO:0051965positive regulation of synapse assembly
BPIEAGO:0060548negative regulation of cell death
BPIEAGO:0070306lens fiber cell differentiation
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071300cellular response to retinoic acid
BPIEAGO:0090102cochlea development
BPIDAGO:0090630activation of GTPase activity
BPIBAGO:1990090cellular response to nerve growth factor stimulus
BPIDAGO:2000251positive regulation of actin cytoskeleton reorganization
CCIBAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIBAGO:0030424axon
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
MFIPIGO:0002039p53 binding
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIEAGO:0005004GPI-linked ephrin receptor activity
MFIBAGO:0005030neurotrophin receptor activity
MFIDAGO:0005030neurotrophin receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIBAGO:0043121neurotrophin binding
MFTASGO:0043121neurotrophin binding

Gene expression in normal tissue: NTRK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NTRK3


DatabasePathway IDPathway Des.
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
pidshp2_pathwaySHP2 signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-388844Receptor-type tyrosine-protein phosphatases
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9034013NTF3 activates NTRK3 signaling
reactomeR-HSA-9034013NTF3 activates NTRK3 signaling
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9034793Activated NTRK3 signals through PLCG1
reactomeR-HSA-9034793Activated NTRK3 signals through PLCG1
reactomeR-HSA-9034864Activated NTRK3 signals through RAS
reactomeR-HSA-9603381Activated NTRK3 signals through PI3K
reactomeR-HSA-9603381Activated NTRK3 signals through PI3K
reactomeR-HSA-9603505NTRK3 as a dependence receptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD494Neopeltolide2
iGMDRD781Sirolimus3
iGMDRD427ABT7371
iGMDRD670ML 2106
iGMDRD144NSC953979
iGMDRD420Leucascandrolide A5
iGMDRD634SCHEMBL26080416
iGMDRD394BX-7955
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD152179324-69-74
iGMDRD61Kinetin riboside7
iGMDRD446LY 21832402
iGMDRD782DC-45-A23
iGMDRD255SB2250022
iGMDRD575Entrectinib1
iGMDRD8024-methylfasudil1
iGMDRD474Avrainvillamide3
iGMDRD138PX 127
iGMDRD23Gossypol5
iGMDRD506Fedratinib5
iGMDRD562Navitoclax2
iGMDRD74Idarubicin3
iGMDRD887Compound 23 citrate5
iGMDRD424Tamatinib3
iGMDRD148Pifithrin-mu2
iGMDRD435BI-25366
iGMDRD154NSC237663
iGMDRD211(1S,3R)-RSL34
iGMDRD314Tanespimycin4
iGMDRD341Triacsin c2
iGMDRD77Itraconazole5
iGMDRD267Oligomycin A3
iGMDRD705Nakiterpiosin3
iGMDRD158NSC1415403
iGMDRD251ML1623
iGMDRD300Tozasertib3
iGMDRD505Pevonedistat2
iGMDRD886Compound 1541A9
iGMDRD147Prima-13
iGMDRD552AZD-17754
iGMDRD662JQ-13
iGMDRD414MST-3126
iGMDRD286Nsc 6328394
iGMDRD67PENFLURIDOL2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NTRK3

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