NTRK3
Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:191316 Ensembl IDEnsembl:ENSG00000140538 HGNC IDHGNC:HGNC:8033 PHARMGKB IDPA31819 Map Location15q25.3 | |||||
GO terms in NTRK3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IDA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | TAS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
Gene expression in normal tissue: NTRK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTRK3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| pid | shp2_pathway | SHP2 signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| reactome | R-HSA-112316 | Neuronal System |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTRK3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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