NTRK3
Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neurotrophic receptor tyrosine kinase 3 | MIM:191316 | Ensembl:ENSG00000140538 | HGNC:HGNC:8033 | PA31819 | 15q25.3 |
GO terms in NTRK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IDA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | TAS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IMP | GO:0007507 | heart development |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0019056 | modulation by virus of host transcription |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0032148 | activation of protein kinase B activity |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0038179 | neurotrophin signaling pathway |
| BP | IEA | GO:0042490 | mechanoreceptor differentiation |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0048665 | neuron fate specification |
| BP | IEA | GO:0048678 | response to axon injury |
| BP | IEA | GO:0048691 | positive regulation of axon extension involved in regeneration |
| BP | IEA | GO:0048712 | negative regulation of astrocyte differentiation |
| BP | IDA | GO:0050927 | positive regulation of positive chemotaxis |
| BP | IEA | GO:0051412 | response to corticosterone |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| BP | IEA | GO:0060548 | negative regulation of cell death |
| BP | IEA | GO:0070306 | lens fiber cell differentiation |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:0090102 | cochlea development |
| BP | IDA | GO:0090630 | activation of GTPase activity |
| BP | IBA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IDA | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0030424 | axon |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0005004 | GPI-linked ephrin receptor activity |
| MF | IBA | GO:0005030 | neurotrophin receptor activity |
| MF | IDA | GO:0005030 | neurotrophin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IBA | GO:0043121 | neurotrophin binding |
| MF | TAS | GO:0043121 | neurotrophin binding |
Gene expression in normal tissue: NTRK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTRK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| pid | shp2_pathway | SHP2 signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-388844 | Receptor-type tyrosine-protein phosphatases |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9034013 | NTF3 activates NTRK3 signaling |
| reactome | R-HSA-9034013 | NTF3 activates NTRK3 signaling |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034793 | Activated NTRK3 signals through PLCG1 |
| reactome | R-HSA-9034793 | Activated NTRK3 signals through PLCG1 |
| reactome | R-HSA-9034864 | Activated NTRK3 signals through RAS |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| reactome | R-HSA-9603505 | NTRK3 as a dependence receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD670 | ML 210 | 6 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD394 | BX-795 | 5 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD61 | Kinetin riboside | 7 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD575 | Entrectinib | 1 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD138 | PX 12 | 7 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 5 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 4 |
| iGMDRD314 | Tanespimycin | 4 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD886 | Compound 1541A | 9 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD552 | AZD-1775 | 4 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD67 | PENFLURIDOL | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTRK3
CLASSFICATION
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