BCKDK
Summary: The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:614901 Ensembl IDEnsembl:ENSG00000103507 HGNC IDHGNC:HGNC:16902 PHARMGKB IDPA134899581 Map Location16p11.2 | |||||
GO terms in BCKDK
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | TAS | GO:0047323 | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity |
| CC | HDA | GO:0005739 | mitochondrion |
Gene expression in normal tissue: BCKDK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCKDK
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-70895 | Branched-chain amino acid catabolism |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCKDK
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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