ITGB8


Summary: This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
integrin subunit beta 8MIM:604160Ensembl:ENSG00000105855HGNC:HGNC:6163PA299627p21.1

GO terms in ITGB8


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005102signaling receptor binding
MFIBAGO:0005178integrin binding
MFIEAGO:0038023signaling receptor activity
MFIDAGO:1990430extracellular matrix protein binding
BPIEAGO:0001573ganglioside metabolic process
BPTASGO:0007155cell adhesion
BPIBAGO:0007160cell-matrix adhesion
BPIMPGO:0007160cell-matrix adhesion
BPIBAGO:0007229integrin-mediated signaling pathway
BPIEAGO:0007229integrin-mediated signaling pathway
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010629negative regulation of gene expression
BPIBAGO:0016477cell migration
BPTASGO:0030198extracellular matrix organization
BPIBAGO:0033627cell adhesion mediated by integrin
BPIMPGO:0045766positive regulation of angiogenesis
BPIMPGO:0051216cartilage development
BPTASGO:0060674placenta blood vessel development
CCTASGO:0005886plasma membrane
CCIBAGO:0005925focal adhesion
CCIBAGO:0008305integrin complex
CCTASGO:0008305integrin complex
CCIBAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIDAGO:0034686integrin alphav-beta8 complex
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ITGB8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGB8


DatabasePathway IDPathway Des.
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-216083Integrin cell surface interactions
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
pidintegrin5_pathwayBeta5 beta6 beta7 and beta8 integrin cell surface interactions
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD474Avrainvillamide3
iGMDRD171Pemetrexed3
iGMDRD441TW 371
iGMDRD870BRD636103
iGMDRD188Piperlongumine3
iGMDRD74Idarubicin1
iGMDRD399Selumetinib3
iGMDRD577BIX012941
iGMDRD506Fedratinib6
iGMDRD60Quinoclamine5
iGMDRD64Parbendazole3
iGMDRD23Gossypol2
iGMDRD524ISX-96
iGMDRD579PF7503
iGMDRD144NSC953973
iGMDRD670ML 2103
iGMDRD494Neopeltolide3
iGMDRD483SCH-5290743
iGMDRD781Sirolimus2
iGMDRD71Sparfosic acid2
iGMDRD718Pyrvinium pamoate3
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B1
iGMDRD634SCHEMBL26080414
iGMDRD137Indisulam1
iGMDRD271Brefeldin A3
iGMDRD121GMX17786
iGMDRD5Tyrphostin AG 14781
iGMDRD286Nsc 6328393
iGMDRD871BRD63683
iGMDRD329Merck605
iGMDRD300Tozasertib1
iGMDRD42Vorinostat1
iGMDRD322FK 8661
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD652UNC06383
iGMDRD57Chloropentafluorobenzene2
iGMDRD351GW843682X1
iGMDRD314Tanespimycin5
iGMDRD237ABT-7514
iGMDRD211(1S,3R)-RSL33
iGMDRD123Isoevodiamine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGB8

​​​​