DYRK3
Summary: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual specificity tyrosine phosphorylation regulated kinase 3 | MIM:603497 | Ensembl:ENSG00000143479 | HGNC:HGNC:3094 | PA27551 | 1q32.1 |
GO terms in DYRK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0030218 | erythrocyte differentiation |
| BP | IMP | GO:0035617 | stress granule disassembly |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| BP | IMP | GO:0080135 | regulation of cellular response to stress |
| BP | IMP | GO:1903432 | regulation of TORC1 signaling |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0010494 | cytoplasmic stress granule |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: DYRK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD718 | Pyrvinium pamoate | 2 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD562 | Navitoclax | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DYRK3
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.