SULF2


Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sulfatase 2MIM:610013Ensembl:ENSG00000196562HGNC:HGNC:20392PA13490213120q13.12

GO terms in SULF2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004065arylsulfatase activity
MFIMPGO:0004065arylsulfatase activity
MFIEAGO:0005509calcium ion binding
MFIDAGO:0008449N-acetylglucosamine-6-sulfatase activity
MFIMPGO:0008449N-acetylglucosamine-6-sulfatase activity
BPISSGO:0001822kidney development
BPISSGO:0002063chondrocyte development
BPISSGO:0003094glomerular filtration
BPIEAGO:0009611response to wounding
BPISSGO:0010575positive regulation of vascular endothelial growth factor production
BPISSGO:0014846esophagus smooth muscle contraction
BPIDAGO:0030177positive regulation of Wnt signaling pathway
BPIDAGO:0030201heparan sulfate proteoglycan metabolic process
BPNASGO:0030201heparan sulfate proteoglycan metabolic process
BPISSGO:0032836glomerular basement membrane development
BPISSGO:0035860glial cell-derived neurotrophic factor receptor signaling pathway
BPISSGO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
BPISSGO:0048706embryonic skeletal system development
BPISSGO:0051216cartilage development
BPISSGO:0060348bone development
BPISSGO:0060384innervation
BPIEAGO:0090263positive regulation of canonical Wnt signaling pathway
BPIEAGO:0097421liver regeneration
BPIEAGO:2000345regulation of hepatocyte proliferation
CCNASGO:0005615extracellular space
CCIDAGO:0005783endoplasmic reticulum
CCIEAGO:0005795Golgi stack
CCISSGO:0005886plasma membrane
CCIDAGO:0009986cell surface

Gene expression in normal tissue: SULF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SULF2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD780PP-304
iGMDRD398Sepantronium2
iGMDRD100Zebularine1
iGMDRD255SB2250023
iGMDRD474Avrainvillamide3
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-71
iGMDRD446LY 21832404
iGMDRD297Austocystin D2
iGMDRD394BX-7953
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B4
iGMDRD599Salermide1
iGMDRD866BRD18123
iGMDRD420Leucascandrolide A4
iGMDRD126Tipifarnib3
iGMDRD546BMS-7548072
iGMDRD329Merck606
iGMDRD871BRD63683
iGMDRD505Pevonedistat1
iGMDRD886Compound 1541A1
iGMDRD147Prima-11
iGMDRD271Brefeldin A1
iGMDRD121GMX17782
iGMDRD158NSC1415402
iGMDRD267Oligomycin A1
iGMDRD351GW843682X1
iGMDRD57Chloropentafluorobenzene1
iGMDRD341Triacsin c3
iGMDRD945ML2142
iGMDRD512nutlin 31
iGMDRD79Gemcitabine1
iGMDRD405PIK-753
iGMDRD116CD4376

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SULF2

​​​​