SULF2
Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namesulfatase 2 OMIM IDMIM:610013 Ensembl IDEnsembl:ENSG00000196562 HGNC IDHGNC:HGNC:20392 PHARMGKB IDPA134902131 Map Location20q13.12 | |||||
GO terms in SULF2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004065 | arylsulfatase activity |
| MF | IMP | GO:0004065 | arylsulfatase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0008449 | N-acetylglucosamine-6-sulfatase activity |
| MF | IMP | GO:0008449 | N-acetylglucosamine-6-sulfatase activity |
| BP | ISS | GO:0001822 | kidney development |
Gene expression in normal tissue: SULF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SULF2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SULF2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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