SULF2
Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sulfatase 2 | MIM:610013 | Ensembl:ENSG00000196562 | HGNC:HGNC:20392 | PA134902131 | 20q13.12 |
GO terms in SULF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004065 | arylsulfatase activity |
| MF | IMP | GO:0004065 | arylsulfatase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0008449 | N-acetylglucosamine-6-sulfatase activity |
| MF | IMP | GO:0008449 | N-acetylglucosamine-6-sulfatase activity |
| BP | ISS | GO:0001822 | kidney development |
| BP | ISS | GO:0002063 | chondrocyte development |
| BP | ISS | GO:0003094 | glomerular filtration |
| BP | IEA | GO:0009611 | response to wounding |
| BP | ISS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | ISS | GO:0014846 | esophagus smooth muscle contraction |
| BP | IDA | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | IDA | GO:0030201 | heparan sulfate proteoglycan metabolic process |
| BP | NAS | GO:0030201 | heparan sulfate proteoglycan metabolic process |
| BP | ISS | GO:0032836 | glomerular basement membrane development |
| BP | ISS | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway |
| BP | ISS | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| BP | ISS | GO:0048706 | embryonic skeletal system development |
| BP | ISS | GO:0051216 | cartilage development |
| BP | ISS | GO:0060348 | bone development |
| BP | ISS | GO:0060384 | innervation |
| BP | IEA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | IEA | GO:2000345 | regulation of hepatocyte proliferation |
| CC | NAS | GO:0005615 | extracellular space |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005795 | Golgi stack |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
Gene expression in normal tissue: SULF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SULF2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD780 | PP-30 | 4 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD866 | BRD1812 | 3 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD116 | CD437 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SULF2
CLASSFICATION
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