STK25
Summary: This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 25 | MIM:602255 | Ensembl:ENSG00000115694 | HGNC:HGNC:11404 | PA36211 | 2q37.3 |
GO terms in STK25
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0007163 | establishment or maintenance of cell polarity |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0032874 | positive regulation of stress-activated MAPK cascade |
| BP | IGI | GO:0036481 | intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
| BP | IDA | GO:0042542 | response to hydrogen peroxide |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0050772 | positive regulation of axonogenesis |
| BP | IDA | GO:0051645 | Golgi localization |
| BP | IMP | GO:0051683 | establishment of Golgi localization |
| BP | IMP | GO:0090168 | Golgi reassembly |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: STK25
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK25
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD446 | LY 2183240 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK25
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