STK25


Summary: This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serine/threonine kinase 25MIM:602255Ensembl:ENSG00000115694HGNC:HGNC:11404PA362112q37.3

GO terms in STK25


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCHDAGO:0070062extracellular exosome
BPIEAGO:0000165MAPK cascade
BPIEAGO:0000185activation of MAPKKK activity
BPIDAGO:0006468protein phosphorylation
BPTASGO:0006979response to oxidative stress
BPIEAGO:0007163establishment or maintenance of cell polarity
BPTASGO:0007165signal transduction
BPIBAGO:0007346regulation of mitotic cell cycle
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIDAGO:0032874positive regulation of stress-activated MAPK cascade
BPIGIGO:0036481intrinsic apoptotic signaling pathway in response to hydrogen peroxide
BPIDAGO:0042542response to hydrogen peroxide
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0050772positive regulation of axonogenesis
BPIDAGO:0051645Golgi localization
BPIMPGO:0051683establishment of Golgi localization
BPIMPGO:0090168Golgi reassembly
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: STK25

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STK25


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide6
iGMDRD705Nakiterpiosin3
iGMDRD255SB2250026
iGMDRD121GMX17785
iGMDRD138PX 123
iGMDRD474Avrainvillamide3
iGMDRD322FK 8666
iGMDRD300Tozasertib2
iGMDRD60Quinoclamine6
iGMDRD246NPC263
iGMDRD506Fedratinib3
iGMDRD577BIX012943
iGMDRD269Purmorphamine2
iGMDRD188Piperlongumine1
iGMDRD286Nsc 6328394
iGMDRD872BRD71373
iGMDRD424Tamatinib3
iGMDRD1008SR-II-138A1
iGMDRD772BRD47703
iGMDRD579PF7502
iGMDRD126Tipifarnib2
iGMDRD945ML2143
iGMDRD154NSC237664
iGMDRD466Chaetocin4
iGMDRD351GW843682X3
iGMDRD446LY 21832403

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STK25

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