CDC42
Summary: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 42 | MIM:116952 | Ensembl:ENSG00000070831 | HGNC:HGNC:1736 | PA26266 | 1p36.12 |
GO terms in CDC42
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006897 | endocytosis |
| BP | IMP | GO:0006911 | phagocytosis, engulfment |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | IMP | GO:0007015 | actin filament organization |
| BP | ISS | GO:0007030 | Golgi organization |
| BP | IBA | GO:0007163 | establishment or maintenance of cell polarity |
| BP | TAS | GO:0007163 | establishment or maintenance of cell polarity |
| BP | IMP | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IBA | GO:0008360 | regulation of cell shape |
| BP | IGI | GO:0010591 | regulation of lamellipodium assembly |
| BP | IMP | GO:0010592 | positive regulation of lamellipodium assembly |
| BP | IBA | GO:0016477 | cell migration |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | HEP | GO:0021762 | substantia nigra development |
| BP | IBA | GO:0030031 | cell projection assembly |
| BP | IBA | GO:0030036 | actin cytoskeleton organization |
| BP | IDA | GO:0030036 | actin cytoskeleton organization |
| BP | TAS | GO:0030225 | macrophage differentiation |
| BP | IMP | GO:0030307 | positive regulation of cell growth |
| BP | IBA | GO:0030865 | cortical cytoskeleton organization |
| BP | IDA | GO:0031274 | positive regulation of pseudopodium assembly |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IPI | GO:0031333 | negative regulation of protein complex assembly |
| BP | IMP | GO:0032467 | positive regulation of cytokinesis |
| BP | IBA | GO:0032488 | Cdc42 protein signal transduction |
| BP | IBA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IMP | GO:0034329 | cell junction assembly |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IMP | GO:0038189 | neuropilin signaling pathway |
| BP | IMP | GO:0039694 | viral RNA genome replication |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IMP | GO:0045198 | establishment of epithelial cell apical/basal polarity |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | TAS | GO:0051149 | positive regulation of muscle cell differentiation |
| BP | IDA | GO:0051489 | regulation of filopodium assembly |
| BP | IMP | GO:0051491 | positive regulation of filopodium assembly |
| BP | ISS | GO:0051491 | positive regulation of filopodium assembly |
| BP | IGI | GO:0051492 | regulation of stress fiber assembly |
| BP | IMP | GO:0051496 | positive regulation of stress fiber assembly |
| BP | ISS | GO:0051683 | establishment of Golgi localization |
| BP | IMP | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore |
| BP | NAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | ISS | GO:0060997 | dendritic spine morphogenesis |
| BP | ISS | GO:0072384 | organelle transport along microtubule |
| BP | IBA | GO:0099563 | modification of synaptic structure |
| BP | IDA | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IMP | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| CC | ISS | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0005938 | cell cortex |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IMP | GO:0017119 | Golgi transport complex |
| CC | IDA | GO:0030175 | filopodium |
| CC | IDA | GO:0030496 | midbody |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
| CC | IBA | GO:0031982 | vesicle |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| CC | IBA | GO:0042995 | cell projection |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043005 | neuron projection |
| CC | IDA | GO:0043025 | neuronal cell body |
| CC | IBA | GO:0043197 | dendritic spine |
| CC | IDA | GO:0043197 | dendritic spine |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0051233 | spindle midzone |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0072686 | mitotic spindle |
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IDA | GO:0003924 | GTPase activity |
| MF | TAS | GO:0003924 | GTPase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005525 | GTP binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0031996 | thioesterase binding |
| MF | IPI | GO:0032427 | GBD domain binding |
| MF | IPI | GO:0034191 | apolipoprotein A-I receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: CDC42
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC42
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2249 | Metastatic brain tumor |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2290 | RalA downstream regulated genes |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cdc42_reg_pathway | Regulation of CDC42 activity |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | endothelinpathway | Endothelins |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | lis1pathway | Lissencephaly gene (LIS1) in neuronal migration and development |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | s1p_s1p4_pathway | S1P4 pathway |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| pharmgkb | PA154423660 | Bisphosphonate Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| biocarta | actinypathway | y branching of actin filaments |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | cdc42racpathway | role of pi3k subunit p85 in regulation of actin organization and cell migration |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| biocarta | raspathway | ras signaling pathway |
| biocarta | salmonellapathway | how does salmonella hijack a cell |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389359 | CD28 dependent Vav1 pathway |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428543 | Inactivation of CDC42 and RAC1 |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-5625970 | RHO GTPases activate KTN1 |
| reactome | R-HSA-5626467 | RHO GTPases activate IQGAPs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC42
CLASSFICATION
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