WDHD1
Summary: The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WD repeat and HMG-box DNA binding protein 1 | MIM:608126 | Ensembl:ENSG00000198554 | HGNC:HGNC:23170 | PA134988782 | 14q22.2-q22.3 |
GO terms in WDHD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000775 | chromosome, centromeric region |
| CC | IEA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0031298 | replication fork protection complex |
| CC | IBA | GO:0043596 | nuclear replication fork |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IBA | GO:0006261 | DNA-dependent DNA replication |
| BP | IBA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006396 | RNA processing |
| BP | IBA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0033044 | regulation of chromosome organization |
| BP | IEA | GO:0070829 | heterochromatin maintenance |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IEA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0070063 | RNA polymerase binding |
Gene expression in normal tissue: WDHD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD294 | Batimastat | 6 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD690 | PRIMA-1MET | 1 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD483 | SCH-529074 | 9 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WDHD1
CLASSFICATION
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