RPS6KA3
Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:300075 Ensembl IDEnsembl:ENSG00000177189 HGNC IDHGNC:HGNC:10432 PHARMGKB IDPA34847 Map LocationXp22.12 |
GO terms in RPS6KA3
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005829 | cytosol |
BP | TAS | GO:0001501 | skeletal system development |
BP | ISS | GO:0002224 | toll-like receptor signaling pathway |
BP | IEA | GO:0006915 | apoptotic process |
BP | IEA | GO:0007049 | cell cycle |
Gene expression in normal tissue: RPS6KA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KA3
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
wikipathways | WP304 | Kit receptor signaling pathway |
wikipathways | WP382 | MAPK Signaling Pathway |
wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
wikipathways | WP437 | EGF-EGFR Signaling Pathway |
wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KA3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |