RPS6KA3


Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribosomal protein S6 kinase A3MIM:300075Ensembl:ENSG00000177189HGNC:HGNC:10432PA34847Xp22.12

GO terms in RPS6KA3


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
BPTASGO:0001501skeletal system development
BPISSGO:0002224toll-like receptor signaling pathway
BPIEAGO:0006915apoptotic process
BPIEAGO:0007049cell cycle
BPTASGO:0007165signal transduction
BPTASGO:0007417central nervous system development
BPTASGO:0018105peptidyl-serine phosphorylation
BPTASGO:0030307positive regulation of cell growth
BPISSGO:0032496response to lipopolysaccharide
BPTASGO:0043066negative regulation of apoptotic process
BPIDAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0043555regulation of translation in response to stress
BPTASGO:0043620regulation of DNA-templated transcription in response to stress
BPTASGO:0045597positive regulation of cell differentiation
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
MFIEAGO:0000287magnesium ion binding
MFTASGO:0004672protein kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004711ribosomal protein S6 kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0016301kinase activity
MFIDAGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Gene expression in normal tissue: RPS6KA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS6KA3


DatabasePathway IDPathway Des.
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP477Cytoplasmic Ribosomal Proteins
wikipathwaysWP481Insulin Signaling
pidar_pathwayCoregulation of Androgen receptor activity
piderbb1_downstream_pathwayErbB1 downstream signaling
pidpdgfrbpathwayPDGFR-beta signaling pathway
netpathPathway_BDNFBDNF
netpathPathway_EGFR1EGFR1
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
biocartadreampathwayrepression of pain sensation by the transcriptional regulator dream
biocartagpcrpathwaysignaling pathway from g-protein families
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-199920CREB phosphorylation
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-437239Recycling pathway of L1
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-444257RSK activation
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD5Tyrphostin AG 14781
iGMDRD103SN-383
iGMDRD158NSC1415403
iGMDRD271Brefeldin A1
iGMDRD77Itraconazole1
iGMDRD434BMS-5369242
iGMDRD329Merck603
iGMDRD286Nsc 6328399
iGMDRD872BRD71372
iGMDRD886Compound 1541A2
iGMDRD246NPC263
iGMDRD148Pifithrin-mu3
iGMDRD330BRD41323
iGMDRD405PIK-753
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD351GW843682X3
iGMDRD314Tanespimycin3
iGMDRD237ABT-7512
iGMDRD85Ursolic acid2
iGMDRD123Isoevodiamine4
iGMDRD441TW 371
iGMDRD171Pemetrexed3
iGMDRD577BIX012945
iGMDRD506Fedratinib2
iGMDRD562Navitoclax2
iGMDRD188Piperlongumine8
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin3
iGMDRD23Gossypol5
iGMDRD64Parbendazole3
iGMDRD889Compound 7d-cis5
iGMDRD579PF7503
iGMDRD494Neopeltolide4
iGMDRD483SCH-5290743
iGMDRD781Sirolimus5
iGMDRD427ABT7375
iGMDRD670ML 2103
iGMDRD446LY 21832404
iGMDRD71Sparfosic acid2
iGMDRD466Chaetocin3
iGMDRD280CYTOCHALASIN B5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA3

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