RPS6KA3
Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S6 kinase A3 | MIM:300075 | Ensembl:ENSG00000177189 | HGNC:HGNC:10432 | PA34847 | Xp22.12 |
GO terms in RPS6KA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | ISS | GO:0002224 | toll-like receptor signaling pathway |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | TAS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0030307 | positive regulation of cell growth |
| BP | ISS | GO:0032496 | response to lipopolysaccharide |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0043555 | regulation of translation in response to stress |
| BP | TAS | GO:0043620 | regulation of DNA-templated transcription in response to stress |
| BP | TAS | GO:0045597 | positive regulation of cell differentiation |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004711 | ribosomal protein S6 kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IDA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
Gene expression in normal tissue: RPS6KA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| wikipathways | WP481 | Insulin Signaling |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-199920 | CREB phosphorylation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-444257 | RSK activation |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 9 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD71 | Sparfosic acid | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KA3
CLASSFICATION
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