RPS6KA3

Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameribosomal protein S6 kinase A3
OMIM IDMIM:300075
Ensembl IDEnsembl:ENSG00000177189
HGNC IDHGNC:HGNC:10432
PHARMGKB IDPA34847
Map LocationXp22.12

GO terms in RPS6KA3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005654 nucleoplasm
CC TAS GO:0005829 cytosol
BP TAS GO:0001501 skeletal system development
BP ISS GO:0002224 toll-like receptor signaling pathway
BP IEA GO:0006915 apoptotic process
BP IEA GO:0007049 cell cycle
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Gene expression in normal tissue: RPS6KA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined31Apoptosis regulation2DNA replication2Biosynthesis of secondary metabolites1Longevity regulating pathway1Other, kinases1One carbon pool by folate1Protein stability and degradation1Cell cycle1

Pathways in RPS6KA3


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Database
Pathway ID
Pathway Des.
wikipathways WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways WP304 Kit receptor signaling pathway
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP437 EGF-EGFR Signaling Pathway
wikipathways WP477 Cytoplasmic Ribosomal Proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD5 Tyrphostin AG 1478 1
iGMDRD103 SN-38 3
iGMDRD158 NSC141540 3
iGMDRD271 Brefeldin A 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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