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CCNG1

Summary: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecyclin G1 OMIM IDMIM:601578 Ensembl IDEnsembl:ENSG00000113328 HGNC IDHGNC:HGNC:1592 PHARMGKB IDPA26157 Map Location5q34

Gene Categories:

SERINE THREONINE KINASE TUMOR SUPPRESSOR KINASE

GO terms in CCNG1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004672	protein kinase activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
MF	IBA	GO:0019901	protein kinase binding
CC	IBA	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
CC	IBA	GO:0005634	nucleus

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Gene expression in normal tissue: CCNG1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNG1

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Database	Pathway ID	Pathway Des.
wikipathways	WP1530	miRNA Regulation of DNA Damage Response
wikipathways	WP2002	miR-targeted genes in epithelium - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2431	Spinal Cord Injury
wikipathways	WP3807	Regulation of TP53 Expression and Degradation
kegg	hsa04115	p53 signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD889	Compound 7d-cis	3
iGMDRD345	Compound 10b [PMID: 11504634]	1
iGMDRD100	Zebularine	6
iGMDRD887	Compound 23 citrate	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNG1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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