CCNG1


Summary: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601578
PHARMGKB IDPA26157
Map Location5q34

GO terms in CCNG1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004672 protein kinase activity
MF IPI GO:0005515 protein binding
MF IBA GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
MF IBA GO:0019901 protein kinase binding
CC IBA GO:0000307 cyclin-dependent protein kinase holoenzyme complex
CC IBA GO:0005634 nucleus
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Gene expression in normal tissue: CCNG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNG1


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Database
Pathway ID
Pathway Des.
wikipathways WP1530 miRNA Regulation of DNA Damage Response
wikipathways WP2002 miR-targeted genes in epithelium - TarBase
wikipathways WP2005 miR-targeted genes in muscle cell - TarBase
wikipathways WP2431 Spinal Cord Injury
wikipathways WP3807 Regulation of TP53 Expression and Degradation
kegg hsa04115 p53 signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD889 Compound 7d-cis 3
iGMDRD345 Compound 10b [PMID: 11504634] 1
iGMDRD100 Zebularine 6
iGMDRD887 Compound 23 citrate 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNG1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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