CCNG1
Summary: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin G1 | MIM:601578 | Ensembl:ENSG00000113328 | HGNC:HGNC:1592 | PA26157 | 5q34 |
GO terms in CCNG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IBA | GO:0019901 | protein kinase binding |
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0051301 | cell division |
Gene expression in normal tissue: CCNG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCNG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3807 | Regulation of TP53 Expression and Degradation |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p53regulationpathway | p53 pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD356 | PNU-74654 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCNG1
CLASSFICATION
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