SNX19


Summary: Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. [provided by RefSeq, Dec 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sorting nexin 19Ensembl:ENSG00000120451HGNC:HGNC:21532PA13490435211q24.3-q25

GO terms in SNX19


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0032266phosphatidylinositol-3-phosphate binding
CCIDAGO:0005737cytoplasm
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIEAGO:0031901early endosome membrane
BPIMPGO:0002062chondrocyte differentiation
BPIEAGO:0006887exocytosis
BPIGIGO:0030073insulin secretion
BPIGIGO:1990502dense core granule maturation

Gene expression in normal tissue: SNX19

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SNX19


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD387CHIR-990213
iGMDRD486Tosedostat1
iGMDRD483SCH-5290746
iGMDRD494Neopeltolide3
iGMDRD781Sirolimus1
iGMDRD116CD4373
iGMDRD670ML 2103
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD237ABT-7511
iGMDRD193Fqi13
iGMDRD901ELCPK3
iGMDRD297Austocystin D3
iGMDRD123Isoevodiamine3
iGMDRD394BX-7951
iGMDRD138PX 121
iGMDRD121GMX17783
iGMDRD705Nakiterpiosin1
iGMDRD434BMS-5369243
iGMDRD366PI-1033
iGMDRD871BRD63683
iGMDRD414MST-3123
iGMDRD534BRD14291
iGMDRD524ISX-93
iGMDRD300Tozasertib3
iGMDRD64Parbendazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SNX19

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