SNX19
Summary: Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sorting nexin 19 | Ensembl:ENSG00000120451 | HGNC:HGNC:21532 | PA134904352 | 11q24.3-q25 |
GO terms in SNX19
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IEA | GO:0031901 | early endosome membrane |
| BP | IMP | GO:0002062 | chondrocyte differentiation |
| BP | IEA | GO:0006887 | exocytosis |
| BP | IGI | GO:0030073 | insulin secretion |
| BP | IGI | GO:1990502 | dense core granule maturation |
Gene expression in normal tissue: SNX19
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SNX19
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD483 | SCH-529074 | 6 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD534 | BRD1429 | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD64 | Parbendazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SNX19
CLASSFICATION
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