CDC42BPB


Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CDC42 binding protein kinase betaMIM:614062Ensembl:ENSG00000198752HGNC:HGNC:1738PA2626814q32.32

GO terms in CDC42BPB


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006468protein phosphorylation
BPISSGO:0006468protein phosphorylation
BPTASGO:0007010cytoskeleton organization
BPTASGO:0007163establishment or maintenance of cell polarity
BPTASGO:0007165signal transduction
BPIMPGO:0016477cell migration
BPIMPGO:0031032actomyosin structure organization
BPISSGO:0031532actin cytoskeleton reorganization
BPIEAGO:0035556intracellular signal transduction
CCIEAGO:0005737cytoplasm
CCTASGO:0005856cytoskeleton
CCIEAGO:0005886plasma membrane
CCISSGO:0005911cell-cell junction
CCISSGO:0030027lamellipodium
CCISSGO:0031252cell leading edge
CCIDAGO:0042641actomyosin
CCHDAGO:0070062extracellular exosome
MFISSGO:0000287magnesium ion binding
MFIDAGO:0004672protein kinase activity
MFISSGO:0004674protein serine/threonine kinase activity
MFISSGO:0005524ATP binding
MFIEAGO:0017048Rho GTPase binding
MFIPIGO:0044877protein-containing complex binding

Gene expression in normal tissue: CDC42BPB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC42BPB


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD546BMS-7548071
iGMDRD427ABT7375
iGMDRD144NSC953972
iGMDRD781Sirolimus2
iGMDRD126Tipifarnib2
iGMDRD151CHM-11
iGMDRD1008SR-II-138A2
iGMDRD297Austocystin D3
iGMDRD446LY 21832401
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD639YK 4-2791
iGMDRD61Kinetin riboside1
iGMDRD193Fqi11
iGMDRD782DC-45-A23
iGMDRD885Compound 1101
iGMDRD513BML-2592
iGMDRD255SB2250022
iGMDRD64Parbendazole2
iGMDRD640CAY106182
iGMDRD60Quinoclamine4
iGMDRD524ISX-93
iGMDRD188Piperlongumine2
iGMDRD887Compound 23 citrate1
iGMDRD577BIX012943
iGMDRD506Fedratinib2
iGMDRD398Sepantronium2
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD405PIK-752
iGMDRD701NVP-AUY9221
iGMDRD48Dexamethasone2
iGMDRD486Tosedostat2
iGMDRD584VER 1550081
iGMDRD123Isoevodiamine1
iGMDRD154NSC237662
iGMDRD698Neratinib2
iGMDRD351GW843682X5
iGMDRD6AM-5803
iGMDRD105Triptolide3
iGMDRD481Dactolisib2
iGMDRD77Itraconazole2
iGMDRD267Oligomycin A2
iGMDRD103SN-384
iGMDRD121GMX17783
iGMDRD202Curcumin4
iGMDRD505Pevonedistat2
iGMDRD414MST-3121
iGMDRD872BRD71373
iGMDRD329Merck604
iGMDRD366PI-1033

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC42BPB

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