GRIK1


Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glutamate ionotropic receptor kainate type subunit 1MIM:138245Ensembl:ENSG00000171189HGNC:HGNC:4579PA2897321q21.3

GO terms in GRIK1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCIBAGO:0032983kainate selective glutamate receptor complex
CCIBAGO:0042734presynaptic membrane
CCIBAGO:0045211postsynaptic membrane
CCIEAGO:0045211postsynaptic membrane
CCIBAGO:0098839postsynaptic density membrane
BPTASGO:0007215glutamate receptor signaling pathway
BPTASGO:0007268chemical synaptic transmission
BPTASGO:0007399nervous system development
BPTASGO:0007417central nervous system development
BPIEAGO:0034220ion transmembrane transport
BPIEAGO:0035235ionotropic glutamate receptor signaling pathway
BPIBAGO:0035249synaptic transmission, glutamatergic
BPIBAGO:0050804modulation of chemical synaptic transmission
BPTASGO:0051966regulation of synaptic transmission, glutamatergic
BPIEAGO:0060079excitatory postsynaptic potential
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
MFIBAGO:0008066glutamate receptor activity
MFTASGO:0015276ligand-gated ion channel activity
MFIBAGO:0015277kainate selective glutamate receptor activity
MFIDAGO:0015277kainate selective glutamate receptor activity
MFIBAGO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Gene expression in normal tissue: GRIK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIK1


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-451306Ionotropic activity of kainate receptors
reactomeR-HSA-451307Activation of Na-permeable kainate receptors
reactomeR-HSA-451308Activation of Ca-permeable Kainate Receptor
reactomeR-HSA-451326Activation of kainate receptors upon glutamate binding
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD123Isoevodiamine3
iGMDRD883CIL55A4
iGMDRD945ML2143
iGMDRD330BRD41326
iGMDRD560MK-22061
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD871BRD63687
iGMDRD872BRD71374
iGMDRD329Merck602
iGMDRD246NPC263
iGMDRD137Indisulam2
iGMDRD251ML1626
iGMDRD316N9-Isopropyl-olomoucine6
iGMDRD193Fqi13
iGMDRD297Austocystin D2
iGMDRD634SCHEMBL26080415
iGMDRD554CHEMBL14341373
iGMDRD387CHIR-990212
iGMDRD599Salermide1
iGMDRD144NSC953973
iGMDRD670ML 2103
iGMDRD494Neopeltolide1
iGMDRD188Piperlongumine5
iGMDRD887Compound 23 citrate4
iGMDRD577BIX012945
iGMDRD398Sepantronium2
iGMDRD562Navitoclax5
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine8
iGMDRD524ISX-93
iGMDRD138PX 123
iGMDRD52Rotenone3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIK1

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