GRIK1
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:138245 Ensembl IDEnsembl:ENSG00000171189 HGNC IDHGNC:HGNC:4579 PHARMGKB IDPA28973 Map Location21q21.3 |
GO terms in GRIK1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0005887 | integral component of plasma membrane |
CC | IEA | GO:0030054 | cell junction |
CC | IBA | GO:0032983 | kainate selective glutamate receptor complex |
CC | IBA | GO:0042734 | presynaptic membrane |
Gene expression in normal tissue: GRIK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIK1
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
reactome | R-HSA-112315 | Transmission across Chemical Synapses |
reactome | R-HSA-112316 | Neuronal System |
reactome | R-HSA-451306 | Ionotropic activity of kainate receptors |
reactome | R-HSA-451307 | Activation of Na-permeable kainate receptors |
reactome | R-HSA-451308 | Activation of Ca-permeable Kainate Receptor |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in GRIK1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |