GRIK1
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamate ionotropic receptor kainate type subunit 1 | MIM:138245 | Ensembl:ENSG00000171189 | HGNC:HGNC:4579 | PA28973 | 21q21.3 |
GO terms in GRIK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0032983 | kainate selective glutamate receptor complex |
| CC | IBA | GO:0042734 | presynaptic membrane |
| CC | IBA | GO:0045211 | postsynaptic membrane |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | IBA | GO:0098839 | postsynaptic density membrane |
| BP | TAS | GO:0007215 | glutamate receptor signaling pathway |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | TAS | GO:0007399 | nervous system development |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | IBA | GO:0035249 | synaptic transmission, glutamatergic |
| BP | IBA | GO:0050804 | modulation of chemical synaptic transmission |
| BP | TAS | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| MF | IEA | GO:0005234 | extracellularly glutamate-gated ion channel activity |
| MF | IBA | GO:0008066 | glutamate receptor activity |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IBA | GO:0015277 | kainate selective glutamate receptor activity |
| MF | IDA | GO:0015277 | kainate selective glutamate receptor activity |
| MF | IBA | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
Gene expression in normal tissue: GRIK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-451306 | Ionotropic activity of kainate receptors |
| reactome | R-HSA-451307 | Activation of Na-permeable kainate receptors |
| reactome | R-HSA-451308 | Activation of Ca-permeable Kainate Receptor |
| reactome | R-HSA-451326 | Activation of kainate receptors upon glutamate binding |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD871 | BRD6368 | 7 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD251 | ML162 | 6 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 6 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 8 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD52 | Rotenone | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIK1
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