GRIK1


Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008].

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GO terms in GRIK1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC TAS GO:0005887 integral component of plasma membrane
CC IEA GO:0030054 cell junction
CC IBA GO:0032983 kainate selective glutamate receptor complex
CC IBA GO:0042734 presynaptic membrane
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Gene expression in normal tissue: GRIK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined27Apoptosis regulation2Biosynthesis of secondary metabolites1WNT signaling1PI3K/MTOR signaling1

Pathways in GRIK1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
reactome R-HSA-112315 Transmission across Chemical Synapses
reactome R-HSA-112316 Neuronal System
reactome R-HSA-451306 Ionotropic activity of kainate receptors
reactome R-HSA-451307 Activation of Na-permeable kainate receptors
reactome R-HSA-451308 Activation of Ca-permeable Kainate Receptor
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD123 Isoevodiamine 3
iGMDRD883 CIL55A 4
iGMDRD945 ML214 3
iGMDRD330 BRD4132 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIK1

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Reference ID
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Cancer
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