PRKD3
Summary: This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607077 Ensembl IDEnsembl:ENSG00000115825 HGNC IDHGNC:HGNC:9408 PHARMGKB IDPA33772 Map Location2p22.2 | |||||
GO terms in PRKD3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IBA | GO:0089700 | protein kinase D signaling |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: PRKD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKD3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP35 | G Protein Signaling Pathways |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKD3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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