PRKD3
Summary: This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase D3 | MIM:607077 | Ensembl:ENSG00000115825 | HGNC:HGNC:9408 | PA33772 | 2p22.2 |
GO terms in PRKD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IBA | GO:0089700 | protein kinase D signaling |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: PRKD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP35 | G Protein Signaling Pathways |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD192 | CIL56 | 3 |
| iGMDRD220 | fumonisin B1 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD193 | Fqi1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKD3
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