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CDC25C

Summary: This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecell division cycle 25C OMIM IDMIM:157680 Ensembl IDEnsembl:ENSG00000158402 HGNC IDHGNC:HGNC:1727 PHARMGKB IDPA100 Map Location5q31.2

Gene Categories:

PROTEIN PHOSPHATASE DRUGGABLE GENOME SERINE THREONINE KINASE KINASE TUMOR SUPPRESSOR

GO terms in CDC25C

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
BP	IBA	GO:0000086	G2/M transition of mitotic cell cycle
BP	IGI	GO:0000086	G2/M transition of mitotic cell cycle
BP	TAS	GO:0000086	G2/M transition of mitotic cell cycle
BP	TAS	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BP	TAS	GO:0007088	regulation of mitotic nuclear division

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Gene expression in normal tissue: CDC25C

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC25C

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Database	Pathway ID	Pathway Des.
biocarta	mprpathway	how progesterone initiates the oocyte maturation
reactome	R-HSA-156711	Polo-like kinase mediated events
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-1643685	Disease
reactome	R-HSA-176187	Activation of ATR in response to replication stress

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD718	Pyrvinium pamoate	2
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD599	Salermide	3
iGMDRD387	CHIR-99021	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC25C

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.