CDC25C
Summary: This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 25C | MIM:157680 | Ensembl:ENSG00000158402 | HGNC:HGNC:1727 | PA100 | 5q31.2 |
GO terms in CDC25C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IGI | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | TAS | GO:0007088 | regulation of mitotic nuclear division |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IBA | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IBA | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0110032 | positive regulation of G2/MI transition of meiotic cell cycle |
| BP | IEA | GO:1902751 | positive regulation of cell cycle G2/M phase transition |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| MF | TAS | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IBA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | NAS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0050699 | WW domain binding |
Gene expression in normal tissue: CDC25C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC25C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP3804 | TP53 Regulates Transcription of Cell Cycle Genes |
| wikipathways | WP707 | DNA Damage Response |
| wikipathways | WP727 | Monoamine Transport |
| pid | atm_pathway | ATM pathway |
| pid | atr_pathway | ATR signaling pathway |
| pid | plk1_pathway | PLK1 signaling events |
| pid | plk3_pathway | PLK3 signaling events |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD718 | Pyrvinium pamoate | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC25C
CLASSFICATION
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