SETDB1
Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SET domain bifurcated 1 | MIM:604396 | Ensembl:ENSG00000143379 | HGNC:HGNC:10761 | PA35679 | 1q21.3 |
GO terms in SETDB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0033273 | response to vitamin |
| BP | IEA | GO:0034968 | histone lysine methylation |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IMP | GO:0090309 | positive regulation of methylation-dependent chromatin silencing |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005694 | chromosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: SETDB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SETDB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| wikipathways | WP2369 | Histone Modifications |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD177 | Teniposide | 5 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD562 | Navitoclax | 7 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD634 | SCHEMBL2608041 | 7 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD781 | Sirolimus | 8 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD579 | PF750 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SETDB1
CLASSFICATION
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