FER
Summary: The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FER tyrosine kinase | MIM:176942 | Ensembl:ENSG00000151422 | HGNC:HGNC:3655 | PA28095 | 5q21.3 |
GO terms in FER
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IDA | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008157 | protein phosphatase 1 binding |
| MF | IDA | GO:0008289 | lipid binding |
| BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
| BP | IMP | GO:0000278 | mitotic cell cycle |
| BP | ISS | GO:0001932 | regulation of protein phosphorylation |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IDA | GO:0007260 | tyrosine phosphorylation of STAT protein |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0010591 | regulation of lamellipodium assembly |
| BP | IEA | GO:0010762 | regulation of fibroblast migration |
| BP | IBA | GO:0016477 | cell migration |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0030838 | positive regulation of actin filament polymerization |
| BP | ISS | GO:0031532 | actin cytoskeleton reorganization |
| BP | ISS | GO:0032496 | response to lipopolysaccharide |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | ISS | GO:0033007 | negative regulation of mast cell activation involved in immune response |
| BP | ISS | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | ISS | GO:0034614 | cellular response to reactive oxygen species |
| BP | ISS | GO:0035426 | extracellular matrix-cell signaling |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0036006 | cellular response to macrophage colony-stimulating factor stimulus |
| BP | ISS | GO:0036119 | response to platelet-derived growth factor |
| BP | ISS | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | ISS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | ISS | GO:0038109 | Kit signaling pathway |
| BP | IMP | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0043304 | regulation of mast cell degranulation |
| BP | ISS | GO:0044331 | cell-cell adhesion mediated by cadherin |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | TAS | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | ISS | GO:0050904 | diapedesis |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0070102 | interleukin-6-mediated signaling pathway |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030054 | cell junction |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
Gene expression in normal tissue: FER
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FER
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD150 | RITA | 7 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD512 | nutlin 3 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FER
CLASSFICATION
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