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FER

Summary: The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameFER tyrosine kinase OMIM IDMIM:176942 Ensembl IDEnsembl:ENSG00000151422 HGNC IDHGNC:HGNC:3655 PHARMGKB IDPA28095 Map Location5q21.3

Gene Categories:

TYROSINE KINASE DRUGGABLE GENOME KINASE

GO terms in FER

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IDA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IBA	GO:0005102	signaling receptor binding
MF	IDA	GO:0005154	epidermal growth factor receptor binding
MF	IPI	GO:0005515	protein binding

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Gene expression in normal tissue: FER

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FER

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1433557	Signaling by SCF-KIT
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
pid	fcer1pathway	Fc-epsilon receptor I signaling in mast cells
pid	kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
pid	ncadherinpathway	N-cadherin signaling events

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD524	ISX-9	2
iGMDRD356	PNU-74654	1
iGMDRD23	Gossypol	1
iGMDRD64	Parbendazole	5

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FER

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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