IL1RN
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:147679 Ensembl IDEnsembl:ENSG00000136689 HGNC IDHGNC:HGNC:6000 PHARMGKB IDPA29816 Map Location2q14.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in IL1RN
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005149 | interleukin-1 receptor binding |
| MF | IBA | GO:0005150 | interleukin-1, type I receptor binding |
| MF | IPI | GO:0005150 | interleukin-1, type I receptor binding |
| MF | IBA | GO:0005151 | interleukin-1, type II receptor binding |
| MF | IPI | GO:0005151 | interleukin-1, type II receptor binding |
Gene expression in normal tissue: IL1RN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL1RN
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | il1rpathway | signal transduction through il1r |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL1RN
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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