IL1RN
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 receptor antagonist | MIM:147679 | Ensembl:ENSG00000136689 | HGNC:HGNC:6000 | PA29816 | 2q14.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL1RN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005149 | interleukin-1 receptor binding |
| MF | IBA | GO:0005150 | interleukin-1, type I receptor binding |
| MF | IPI | GO:0005150 | interleukin-1, type I receptor binding |
| MF | IBA | GO:0005151 | interleukin-1, type II receptor binding |
| MF | IPI | GO:0005151 | interleukin-1, type II receptor binding |
| MF | IDA | GO:0005152 | interleukin-1 receptor antagonist activity |
| MF | TAS | GO:0005152 | interleukin-1 receptor antagonist activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0045352 | interleukin-1 type I receptor antagonist activity |
| MF | IDA | GO:0045352 | interleukin-1 type I receptor antagonist activity |
| MF | IBA | GO:0045353 | interleukin-1 type II receptor antagonist activity |
| MF | IDA | GO:0045353 | interleukin-1 type II receptor antagonist activity |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | NAS | GO:0005622 | intracellular |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0001660 | fever generation |
| BP | IBA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | IBA | GO:0002439 | chronic inflammatory response to antigenic stimulus |
| BP | IBA | GO:0006629 | lipid metabolic process |
| BP | IEA | GO:0006629 | lipid metabolic process |
| BP | NAS | GO:0006955 | immune response |
| BP | IBA | GO:0007565 | female pregnancy |
| BP | IBA | GO:0007613 | memory |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0014050 | negative regulation of glutamate secretion |
| BP | IBA | GO:0014823 | response to activity |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0019233 | sensory perception of pain |
| BP | IBA | GO:0019752 | carboxylic acid metabolic process |
| BP | IBA | GO:0030073 | insulin secretion |
| BP | IEA | GO:0030073 | insulin secretion |
| BP | IBA | GO:0030336 | negative regulation of cell migration |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IBA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IBA | GO:0034115 | negative regulation of heterotypic cell-cell adhesion |
| BP | IDA | GO:0034115 | negative regulation of heterotypic cell-cell adhesion |
| BP | IBA | GO:0042493 | response to drug |
| BP | IBA | GO:0042594 | response to starvation |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IBA | GO:0045837 | negative regulation of membrane potential |
| BP | IBA | GO:0046330 | positive regulation of JNK cascade |
| BP | IBA | GO:0051384 | response to glucocorticoid |
| BP | IDA | GO:0051384 | response to glucocorticoid |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IBA | GO:0070555 | response to interleukin-1 |
| BP | IBA | GO:0070670 | response to interleukin-4 |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IBA | GO:0071874 | cellular response to norepinephrine stimulus |
| BP | IBA | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway |
| BP | IDA | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway |
Gene expression in normal tissue: IL1RN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL1RN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | il1rpathway | signal transduction through il1r |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pid | il1pathway | IL1-mediated signaling events |
| netpath | Pathway_IL1 | IL1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD451 | Serdemetan | 6 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 6 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD177 | Teniposide | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL1RN
CLASSFICATION
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