EIF4G1
Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600495 Ensembl IDEnsembl:ENSG00000114867 HGNC IDHGNC:HGNC:3296 PHARMGKB IDPA27722 Map Location3q27.1 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in EIF4G1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | IEA | GO:0001662 | behavioral fear response |
| BP | TAS | GO:0002191 | cap-dependent translational initiation |
| BP | IMP | GO:0006412 | translation |
| BP | IPI | GO:0006412 | translation |
| BP | NAS | GO:0006413 | translational initiation |
Gene expression in normal tissue: EIF4G1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF4G1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP107 | Translation Factors |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF4G1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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