EIF4G1


Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
eukaryotic translation initiation factor 4 gamma 1MIM:600495Ensembl:ENSG00000114867HGNC:HGNC:3296PA277223q27.1

Gene Categories:

TUMOR SUPPRESSOR

GO terms in EIF4G1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPIEAGO:0001662behavioral fear response
BPTASGO:0002191cap-dependent translational initiation
BPIMPGO:0006412translation
BPIPIGO:0006412translation
BPNASGO:0006413translational initiation
BPTASGO:0006413translational initiation
BPIMPGO:0006446regulation of translational initiation
BPNASGO:0006446regulation of translational initiation
BPIMPGO:0007005mitochondrion organization
BPIMPGO:0008284positive regulation of cell proliferation
BPIMPGO:0010507negative regulation of autophagy
BPIMPGO:0010801negative regulation of peptidyl-threonine phosphorylation
BPIGIGO:0010942positive regulation of cell death
BPIEAGO:0016032viral process
BPIMPGO:0030307positive regulation of cell growth
BPIMPGO:0031669cellular response to nutrient levels
BPIMPGO:0032270positive regulation of cellular protein metabolic process
BPTASGO:0032502developmental process
BPIMPGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIGIGO:0034645cellular macromolecule biosynthetic process
BPTASGO:0043488regulation of mRNA stability
BPIEAGO:0045666positive regulation of neuron differentiation
BPTASGO:0060964regulation of gene silencing by miRNA
BPTASGO:0080135regulation of cellular response to stress
BPIMPGO:0097009energy homeostasis
BPIMPGO:1900087positive regulation of G1/S transition of mitotic cell cycle
BPTASGO:1901215negative regulation of neuron death
BPIMPGO:1905537positive regulation of eukaryotic translation initiation factor 4F complex assembly
BPIGIGO:1905606regulation of presynapse assembly
BPIDAGO:1905612positive regulation of mRNA cap binding
BPIDAGO:1905618positive regulation of miRNA mediated inhibition of translation
BPIMPGO:1905696regulation of polysome binding
CCIMPGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIMPGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIMPGO:0005844polysome
CCHDAGO:0016020membrane
CCIBAGO:0016281eukaryotic translation initiation factor 4F complex
CCIDAGO:0016281eukaryotic translation initiation factor 4F complex
CCTASGO:0022627cytosolic small ribosomal subunit
MFHDAGO:0003723RNA binding
MFTASGO:0003723RNA binding
MFIBAGO:0003729mRNA binding
MFIDAGO:0003729mRNA binding
MFIBAGO:0003743translation initiation factor activity
MFTASGO:0003743translation initiation factor activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIMPGO:0008135translation factor activity, RNA binding
MFIDAGO:0008190eukaryotic initiation factor 4E binding
MFTASGO:0008190eukaryotic initiation factor 4E binding
MFTASGO:0031369translation initiation factor binding
MFTASGO:0032947protein-containing complex scaffold activity
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: EIF4G1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EIF4G1


DatabasePathway IDPathway Des.
wikipathwaysWP107Translation Factors
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaeifpathwayeukaryotic protein translation
biocartaigf1mtorpathwayskeletal muscle hypertrophy is regulated via akt-mtor pathway
biocartairespathwayinternal ribosome entry pathway
biocartamtorpathwaymtor signaling pathway
reactomeR-HSA-1169408ISG15 antiviral mechanism
reactomeR-HSA-1169410Antiviral mechanism by IFN-stimulated genes
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expression
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-165159mTOR signalling
reactomeR-HSA-166208mTORC1-mediated signalling
reactomeR-HSA-168256Immune System
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-429914Deadenylation-dependent mRNA decay
reactomeR-HSA-429947Deadenylation of mRNA
reactomeR-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72649Translation initiation complex formation
reactomeR-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
reactomeR-HSA-72702Ribosomal scanning and start codon recognition
reactomeR-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunit
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72766Translation
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD322FK 8665
iGMDRD286Nsc 6328392
iGMDRD6AM-5802
iGMDRD705Nakiterpiosin2
iGMDRD103SN-382
iGMDRD158NSC1415402
iGMDRD121GMX17785
iGMDRD154NSC237664
iGMDRD901ELCPK2
iGMDRD123Isoevodiamine3
iGMDRD351GW843682X3
iGMDRD237ABT-7511
iGMDRD85Ursolic acid2
iGMDRD150RITA3
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD451Serdemetan5
iGMDRD64Parbendazole1
iGMDRD780PP-302
iGMDRD100Zebularine2
iGMDRD188Piperlongumine3
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib2
iGMDRD318PAC-11
iGMDRD187BRD98764
iGMDRD782DC-45-A22
iGMDRD255SB2250021
iGMDRD260FQI-25
iGMDRD138PX 124
iGMDRD466Chaetocin2
iGMDRD639YK 4-2793
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside1
iGMDRD193Fqi14
iGMDRD494Neopeltolide5
iGMDRD781Sirolimus2
iGMDRD670ML 2101
iGMDRD144NSC953973
iGMDRD387CHIR-990212
iGMDRD772BRD47701
iGMDRD420Leucascandrolide A4
iGMDRD126Tipifarnib2
iGMDRD433Lexibulin3
iGMDRD151CHM-15

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EIF4G1

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