EIF4G1
Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 4 gamma 1 | MIM:600495 | Ensembl:ENSG00000114867 | HGNC:HGNC:3296 | PA27722 | 3q27.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in EIF4G1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | IEA | GO:0001662 | behavioral fear response |
| BP | TAS | GO:0002191 | cap-dependent translational initiation |
| BP | IMP | GO:0006412 | translation |
| BP | IPI | GO:0006412 | translation |
| BP | NAS | GO:0006413 | translational initiation |
| BP | TAS | GO:0006413 | translational initiation |
| BP | IMP | GO:0006446 | regulation of translational initiation |
| BP | NAS | GO:0006446 | regulation of translational initiation |
| BP | IMP | GO:0007005 | mitochondrion organization |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010507 | negative regulation of autophagy |
| BP | IMP | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| BP | IGI | GO:0010942 | positive regulation of cell death |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0030307 | positive regulation of cell growth |
| BP | IMP | GO:0031669 | cellular response to nutrient levels |
| BP | IMP | GO:0032270 | positive regulation of cellular protein metabolic process |
| BP | TAS | GO:0032502 | developmental process |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IGI | GO:0034645 | cellular macromolecule biosynthetic process |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | TAS | GO:0060964 | regulation of gene silencing by miRNA |
| BP | TAS | GO:0080135 | regulation of cellular response to stress |
| BP | IMP | GO:0097009 | energy homeostasis |
| BP | IMP | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| BP | TAS | GO:1901215 | negative regulation of neuron death |
| BP | IMP | GO:1905537 | positive regulation of eukaryotic translation initiation factor 4F complex assembly |
| BP | IGI | GO:1905606 | regulation of presynapse assembly |
| BP | IDA | GO:1905612 | positive regulation of mRNA cap binding |
| BP | IDA | GO:1905618 | positive regulation of miRNA mediated inhibition of translation |
| BP | IMP | GO:1905696 | regulation of polysome binding |
| CC | IMP | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IMP | GO:0005844 | polysome |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| CC | IDA | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| CC | TAS | GO:0022627 | cytosolic small ribosomal subunit |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0003723 | RNA binding |
| MF | IBA | GO:0003729 | mRNA binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0003743 | translation initiation factor activity |
| MF | TAS | GO:0003743 | translation initiation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IMP | GO:0008135 | translation factor activity, RNA binding |
| MF | IDA | GO:0008190 | eukaryotic initiation factor 4E binding |
| MF | TAS | GO:0008190 | eukaryotic initiation factor 4E binding |
| MF | TAS | GO:0031369 | translation initiation factor binding |
| MF | TAS | GO:0032947 | protein-containing complex scaffold activity |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: EIF4G1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF4G1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP107 | Translation Factors |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | eifpathway | eukaryotic protein translation |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-429947 | Deadenylation of mRNA |
| reactome | R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
| reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD322 | FK 866 | 5 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD260 | FQI-2 | 5 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF4G1
CLASSFICATION
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