MAP4K4
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase kinase 4 | MIM:604666 | Ensembl:ENSG00000071054 | HGNC:HGNC:6866 | PA30612 | 2q11.2 |
GO terms in MAP4K4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004111 | creatine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IMP | GO:0030033 | microvillus assembly |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0046328 | regulation of JNK cascade |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | IEA | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IEA | GO:0070571 | negative regulation of neuron projection regeneration |
Gene expression in normal tissue: MAP4K4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP4K4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cd40pathway | cd40l signaling pathway |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | rnapathway | double stranded rna induced gene expression |
| biocarta | stresspathway | tnf/stress related signaling |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| wikipathways | WP3404 | Oxidative Stress Induced Senescence |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | tnfpathway | TNF receptor signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD441 | TW 37 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD85 | Ursolic acid | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP4K4
CLASSFICATION
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