ERN1
Summary: This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endoplasmic reticulum to nucleus signaling 1 | MIM:604033 | Ensembl:ENSG00000178607 | HGNC:HGNC:3449 | PA27861 | 17q23.3 |
GO terms in ERN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004521 | endoribonuclease activity |
| MF | TAS | GO:0004521 | endoribonuclease activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0030544 | Hsp70 protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0043531 | ADP binding |
| MF | IDA | GO:0051879 | Hsp90 protein binding |
| CC | IEA | GO:0005637 | nuclear inner membrane |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0030176 | integral component of endoplasmic reticulum membrane |
| CC | NAS | GO:1990332 | Ire1 complex |
| CC | IEA | GO:1990597 | AIP1-IRE1 complex |
| CC | IDA | GO:1990604 | IRE1-TRAF2-ASK1 complex |
| CC | IDA | GO:1990630 | IRE1-RACK1-PP2A complex |
| BP | IDA | GO:0001935 | endothelial cell proliferation |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | ISS | GO:0006379 | mRNA cleavage |
| BP | TAS | GO:0006402 | mRNA catabolic process |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0007050 | cell cycle arrest |
| BP | IDA | GO:0007257 | activation of JUN kinase activity |
| BP | TAS | GO:0016241 | regulation of macroautophagy |
| BP | IDA | GO:0033120 | positive regulation of RNA splicing |
| BP | IDA | GO:0034620 | cellular response to unfolded protein |
| BP | IMP | GO:0034620 | cellular response to unfolded protein |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IDA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IDA | GO:0036289 | peptidyl-serine autophosphorylation |
| BP | IDA | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0070054 | mRNA splicing, via endonucleolytic cleavage and ligation |
| BP | IMP | GO:0070054 | mRNA splicing, via endonucleolytic cleavage and ligation |
| BP | TAS | GO:0070054 | mRNA splicing, via endonucleolytic cleavage and ligation |
| BP | IEA | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IDA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
| BP | IDA | GO:0098787 | mRNA cleavage involved in mRNA processing |
| BP | IMP | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response |
| BP | IDA | GO:1901142 | insulin metabolic process |
| BP | IMP | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| BP | IMP | GO:1990579 | peptidyl-serine trans-autophosphorylation |
Gene expression in normal tissue: ERN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD524 | ISX-9 | 4 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD546 | BMS-754807 | 6 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD871 | BRD6368 | 9 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD47 | ZM336372 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERN1
CLASSFICATION
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