NOTCH2
Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Namenotch 2 OMIM IDMIM:600275 Ensembl IDEnsembl:ENSG00000134250 HGNC IDHGNC:HGNC:7882 PHARMGKB IDPA31684 Map Location1p12 |
GO terms in NOTCH2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0001709 | cell fate determination |
BP | ISS | GO:0002315 | marginal zone B cell differentiation |
BP | IMP | GO:0003184 | pulmonary valve morphogenesis |
BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
BP | TAS | GO:0006915 | apoptotic process |
Gene expression in normal tissue: NOTCH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NOTCH2
Database | Pathway ID | Pathway Des. |
---|---|---|
netpath | Pathway_Notch | Notch |
pid | notch_pathway | Notch signaling pathway |
kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in NOTCH2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |