NOTCH2


Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:600275
PHARMGKB IDPA31684
Map Location1p12

GO terms in NOTCH2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0001709 cell fate determination
BP ISS GO:0002315 marginal zone B cell differentiation
BP IMP GO:0003184 pulmonary valve morphogenesis
BP TAS GO:0006355 regulation of transcription, DNA-templated
BP TAS GO:0006367 transcription initiation from RNA polymerase II promoter
BP TAS GO:0006915 apoptotic process
Showing 1 to 6 of 39 rows rows per page

Gene expression in normal tissue: NOTCH2

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 5undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 57undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 3BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1

Gene-drug pathway distribution

undefined23Chromatin histone acetylation1Apoptosis regulation1Mitosis1Genome integrity1Cell cycle1Proteasome1

Pathways in NOTCH2


Loading, please wait...
Database
Pathway ID
Pathway Des.
netpath Pathway_Notch Notch
pid notch_pathway Notch signaling pathway
kegg hsa04330 Notch signaling pathway - Homo sapiens (human)
kegg hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
kegg hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
kegg hsa05165 Human papillomavirus infection - Homo sapiens (human)
Showing 1 to 6 of 46 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD901 ELCPK 3
iGMDRD123 Isoevodiamine 1
iGMDRD634 SCHEMBL2608041 5
iGMDRD639 YK 4-279 3
Showing 1 to 4 of 29 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NOTCH2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​