iGMDRD525


Canonical SMILES: CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

InChI: InChI=1S/C26H41N3O5/c1-6-7-13-21(16-30)27-24(31)22(14-18(2)3)28-25(32)23(15-19(4)5)29-26(33)34-17-20-11-9-8-10-12-20/h8-12,16,18-19,21-23H,6-7,13-15,17H2,1-5H3,(H,27,31)(H,28,32)(H,29,33)

InChI Key: RNPDUXVFGTULLP-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameGamma secretase inhibitor
Pubchem CID21741800
Drug StatusFamily
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Lymphoid Leukemia (ALL) model num: 25BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 2BREASTtissue: BREAST cancer: Breast Carcinoma model num: 4LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Mantle Cell Lymphoma (MCL) model num: 2

Drug-gene pathway enrichments

6wikipathways: Notch Signaling Pathway4reactome: Signaling by NOTCH4reactome: Pre-NOTCH Expression and Processing4reactome: Pre-NOTCH Processing in Golgi4reactome: Signal Transduction3reactome: Pre-NOTCH Transcription and Translation3reactome: RNA Polymerase II Transcription3reactome: Gene expression (Transcription)3reactome: Generic Transcription Pathway2kegg: Pathways in cancer - Homo sapiens (human)

Drug-gene GO enrichments

5BP: Notch signaling pathway4CC: plasma membrane3BP: aortic valve morphogenesis3CC: nucleus3CC: nucleoplasm3BP: pulmonary valve morphogenesis2BP: negative regulation of gene expression2BP: positive regulation of transcription by RNA polymerase II2BP: positive regulation of cell proliferation2BP: transcription initiation from RNA polymerase II promoter

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4851 NOTCH1 27
4853 NOTCH2 1
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Gene in drug-gene network: Network Plot

ELCPKELCPKIdarubicinIdarubicinquinoclaminequinoclaminePNU-74654PNU-74654GW-843682XGW-843682XparbendazoleparbendazoleYK.4.279YK.4.279SepantroniumSepantroniumVX-680VX-680Nsc 632839Nsc 632839Compound 10b [PMID: 11504634]Compound 10b [PMID: 11504634]OlaparibOlaparibSCHEMBL2608041SCHEMBL2608041zebularinezebularinenutlin 3nutlin 3indisulamindisulamFQI-2FQI-2kahalalide Fkahalalide FCHM-1CHM-1NOTCH2NOTCH2steroids in early settingsteroids in early settingRo4929097Ro4929097lovastatin acidlovastatin acidSB225002SB225002Pf-03084014Pf-03084014Mk-0752Mk-0752NOTCH1NOTCH1Gamma secretase inhibitorsGamma secretase inhibitors

Models in Gamma secretase inhibitor

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
MUT(NOTC0or truncating in Cterm domain) gene ASCO 2006 (abstr 6585) BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 15472075 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 19778842 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 22510873 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 23001755 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 16688224 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 23033986 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 19246562 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 19318552 BLOOD Acute Lymphoid Leukemia (ALL) Gamma secretase inhibitor sensitivity in vivo
D-MUT(NOTCH1 TAD)|MUT(NOTCH truncating in Cterm domain) gene 22101766 BREAST Invasive Breast Carcinoma (BRCA) Gamma secretase inhibitor sensitivity in vivo
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