LIMK1
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIM domain kinase 1 | MIM:601329 | Ensembl:ENSG00000106683 | HGNC:HGNC:6613 | PA30386 | 7q11.23 |
GO terms in LIMK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0016020 | membrane |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | IBA | GO:0043005 | neuron projection |
| CC | ISS | GO:0043005 | neuron projection |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007266 | Rho protein signal transduction |
| BP | TAS | GO:0007399 | nervous system development |
| BP | TAS | GO:0030036 | actin cytoskeleton organization |
| BP | IDA | GO:0032233 | positive regulation of actin filament bundle assembly |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | ISS | GO:0045773 | positive regulation of axon extension |
| BP | IDA | GO:0051444 | negative regulation of ubiquitin-protein transferase activity |
| MF | NAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0031072 | heat shock protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: LIMK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LIMK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rhoa_pathway | RhoA signaling pathway |
| netpath | Pathway_Leptin | Leptin |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-399954 | Sema3A PAK dependent Axon repulsion |
| reactome | R-HSA-399954 | Sema3A PAK dependent Axon repulsion |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | rhopathway | rho cell motility signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD64 | Parbendazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LIMK1
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