LIMK1
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:601329 Ensembl IDEnsembl:ENSG00000106683 HGNC IDHGNC:HGNC:6613 PHARMGKB IDPA30386 Map Location7q11.23 |
GO terms in LIMK1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IEA | GO:0005925 | focal adhesion |
CC | IEA | GO:0016020 | membrane |
Gene expression in normal tissue: LIMK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LIMK1
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | caspase_pathway | Caspase Cascade in Apoptosis |
pid | cdc42_pathway | CDC42 signaling events |
pid | cxcr4_pathway | CXCR4-mediated signaling events |
pid | rac1_pathway | RAC1 signaling pathway |
pid | rhoa_pathway | RhoA signaling pathway |
netpath | Pathway_Leptin | Leptin |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in LIMK1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |