LIMK1


Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601329
PHARMGKB IDPA30386
Map Location7q11.23

GO terms in LIMK1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005737 cytoplasm
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC IEA GO:0005925 focal adhesion
CC IEA GO:0016020 membrane
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Gene expression in normal tissue: LIMK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LIMK1


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Database
Pathway ID
Pathway Des.
pid caspase_pathway Caspase Cascade in Apoptosis
pid cdc42_pathway CDC42 signaling events
pid cxcr4_pathway CXCR4-mediated signaling events
pid rac1_pathway RAC1 signaling pathway
pid rhoa_pathway RhoA signaling pathway
netpath Pathway_Leptin Leptin
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD512 nutlin 3 2
iGMDRD330 BRD4132 2
iGMDRD523 Cyanoquinoline, 11 2
iGMDRD345 Compound 10b [PMID: 11504634] 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LIMK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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