SHC1
Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SHC adaptor protein 1 | MIM:600560 | Ensembl:ENSG00000160691 | HGNC:HGNC:10840 | PA35746 | 1q21.3 |
GO terms in SHC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | TAS | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | ISS | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005159 | insulin-like growth factor receptor binding |
| MF | IPI | GO:0005168 | neurotrophin TRKA receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005543 | phospholipid binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0030971 | receptor tyrosine kinase binding |
| MF | IPI | GO:0046875 | ephrin receptor binding |
| MF | IEA | GO:0048408 | epidermal growth factor binding |
| CC | IEA | GO:0005759 | mitochondrial matrix |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0070435 | Shc-EGFR complex |
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IBA | GO:0000187 | activation of MAPK activity |
| BP | IDA | GO:0000187 | activation of MAPK activity |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007176 | regulation of epidermal growth factor-activated receptor activity |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0007507 | heart development |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | NAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0008286 | insulin receptor signaling pathway |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | TAS | GO:0008286 | insulin receptor signaling pathway |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0031532 | actin cytoskeleton reorganization |
| BP | TAS | GO:0035723 | interleukin-15-mediated signaling pathway |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IMP | GO:0042742 | defense response to bacterium |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0071363 | cellular response to growth factor stimulus |
| BP | IEA | GO:0098609 | cell-cell adhesion |
Gene expression in normal tissue: SHC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SHC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00391 | Insulin Signalling |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | epopathway | EPO signaling pathway |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | et_egfrpathway | EGFR-dependent Endothelin signaling events |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | igf1_pathway | IGF1 pathway |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TCR | TCR |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cdk5pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | epopathway | epo signaling pathway |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il3pathway | il 3 signaling pathway |
| biocarta | il4pathway | il 4 signaling pathway |
| biocarta | il6pathway | il 6 signaling pathway |
| biocarta | insulinpathway | insulin signaling pathway |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | longevitypathway | the igf-1 receptor and longevity |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | smrtepathway | map kinase inactivation of smrt corepressor |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250347 | SHC1 events in ERBB4 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-180336 | SHC1 events in EGFR signaling |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428933 | SHC-related events triggered by IGF1R |
| reactome | R-HSA-2428933 | SHC-related events triggered by IGF1R |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654688 | SHC-mediated cascade:FGFR1 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654699 | SHC-mediated cascade:FGFR2 |
| reactome | R-HSA-5654704 | SHC-mediated cascade:FGFR3 |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654719 | SHC-mediated cascade:FGFR4 |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-74749 | Signal attenuation |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-8851805 | MET activates RAS signaling |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-9026519 | Activated NTRK2 signals through RAS |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034864 | Activated NTRK3 signals through RAS |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 4 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD802 | 4-methylfasudil | 6 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD74 | Idarubicin | 7 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD483 | SCH-529074 | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD466 | Chaetocin | 5 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 7 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD945 | ML214 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SHC1
CLASSFICATION
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