SHC1
Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600560 Ensembl IDEnsembl:ENSG00000160691 HGNC IDHGNC:HGNC:10840 PHARMGKB IDPA35746 Map Location1q21.3 | |||||
GO terms in SHC1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | TAS | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | ISS | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005159 | insulin-like growth factor receptor binding |
Gene expression in normal tissue: SHC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SHC1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00391 | Insulin Signalling |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SHC1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.