STAG3


Summary: The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
stromal antigen 3MIM:608489Ensembl:ENSG00000066923HGNC:HGNC:11356PA361787q22.1

GO terms in STAG3


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007130synaptonemal complex assembly
CCIEAGO:0000775chromosome, centromeric region
CCTASGO:0000795synaptonemal complex
CCHDAGO:0005615extracellular space
CCTASGO:0005634nucleus
CCIDAGO:0030893meiotic cohesin complex

Gene expression in normal tissue: STAG3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STAG3


DatabasePathway IDPathway Des.
reactomeR-HSA-1221632Meiotic synapsis
reactomeR-HSA-1474165Reproduction
reactomeR-HSA-1500620Meiosis
reactomeR-HSA-1640170Cell Cycle
kegghsa04114Oocyte meiosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD154NSC237663
iGMDRD61Kinetin riboside3
iGMDRD152179324-69-71
iGMDRD446LY 21832403
iGMDRD781Sirolimus2
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD512nutlin 37
iGMDRD772BRD47703
iGMDRD151CHM-13
iGMDRD322FK 8663
iGMDRD886Compound 1541A2
iGMDRD871BRD63682
iGMDRD188Piperlongumine3
iGMDRD367Ro 28-16753
iGMDRD887Compound 23 citrate3
iGMDRD596Vemurafenib1
iGMDRD705Nakiterpiosin3
iGMDRD251ML1623
iGMDRD121GMX17787

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAG3

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