STAG3
Summary: The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| stromal antigen 3 | MIM:608489 | Ensembl:ENSG00000066923 | HGNC:HGNC:11356 | PA36178 | 7q22.1 |
GO terms in STAG3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007130 | synaptonemal complex assembly |
| CC | IEA | GO:0000775 | chromosome, centromeric region |
| CC | TAS | GO:0000795 | synaptonemal complex |
| CC | HDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0030893 | meiotic cohesin complex |
Gene expression in normal tissue: STAG3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAG3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1221632 | Meiotic synapsis |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-1640170 | Cell Cycle |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD512 | nutlin 3 | 7 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD596 | Vemurafenib | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD121 | GMX1778 | 7 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAG3
CLASSFICATION
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