STAG3

Summary: The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namestromal antigen 3
OMIM IDMIM:608489
Ensembl IDEnsembl:ENSG00000066923
HGNC IDHGNC:HGNC:11356
PHARMGKB IDPA36178
Map Location7q22.1

GO terms in STAG3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0007130 synaptonemal complex assembly
CC IEA GO:0000775 chromosome, centromeric region
CC TAS GO:0000795 synaptonemal complex
CC HDA GO:0005615 extracellular space
CC TAS GO:0005634 nucleus
CC IDA GO:0030893 meiotic cohesin complex
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Gene expression in normal tissue: STAG3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 47BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Melanoma (MEL) model num: 1

Gene-drug pathway distribution

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Pathways in STAG3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1221632 Meiotic synapsis
reactome R-HSA-1474165 Reproduction
reactome R-HSA-1500620 Meiosis
reactome R-HSA-1640170 Cell Cycle
kegg hsa04114 Oocyte meiosis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD154 NSC23766 3
iGMDRD61 Kinetin riboside 3
iGMDRD152 179324-69-7 1
iGMDRD446 LY 2183240 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAG3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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