TESK2
Summary: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| testis associated actin remodelling kinase 2 | MIM:604746 | Ensembl:ENSG00000070759 | HGNC:HGNC:11732 | PA36449 | 1p34.1 |
GO terms in TESK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0030036 | actin cytoskeleton organization |
| BP | ISS | GO:0048041 | focal adhesion assembly |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016604 | nuclear body |
Gene expression in normal tissue: TESK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TESK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP306 | Focal Adhesion |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD103 | SN-38 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TESK2
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