CDK19
Summary: This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 19 | MIM:614720 | Ensembl:ENSG00000155111 | HGNC:HGNC:19338 | PA165617767 | 6q21 |
GO terms in CDK19
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005829 | cytosol |
| CC | IBA | GO:0016592 | mediator complex |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0050729 | positive regulation of inflammatory response |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019899 | enzyme binding |
Gene expression in normal tissue: CDK19
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK19
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD57 | Chloropentafluorobenzene | 6 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD100 | Zebularine | 7 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK19
CLASSFICATION
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