TP53RK
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TP53 regulating kinase | MIM:608679 | Ensembl:ENSG00000172315 | HGNC:HGNC:16197 | PA25774 | 20q13.12 |
GO terms in TP53RK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0002039 | p53 binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0016787 | hydrolase activity |
| CC | IBA | GO:0000408 | EKC/KEOPS complex |
| CC | IDA | GO:0000408 | EKC/KEOPS complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0008033 | tRNA processing |
| BP | IBA | GO:0070525 | tRNA threonylcarbamoyladenosine metabolic process |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
Gene expression in normal tissue: TP53RK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TP53RK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6782315 | tRNA modification in the nucleus and cytosol |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD579 | PF750 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TP53RK
CLASSFICATION
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