PLAT


Summary: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
plasminogen activator, tissue typeMIM:173370Ensembl:ENSG00000104368HGNC:HGNC:9051PA333818p11.21

GO terms in PLAT


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001666response to hypoxia
BPTASGO:0006464cellular protein modification process
BPIBAGO:0006508proteolysis
BPTASGO:0006508proteolysis
BPTASGO:0007596blood coagulation
BPIBAGO:0014909smooth muscle cell migration
BPIEAGO:0014909smooth muscle cell migration
BPIBAGO:0031639plasminogen activation
BPIDAGO:0031639plasminogen activation
BPTASGO:0042730fibrinolysis
BPIDAGO:0045861negative regulation of proteolysis
BPIBAGO:0048008platelet-derived growth factor receptor signaling pathway
BPIEAGO:0048008platelet-derived growth factor receptor signaling pathway
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005737cytoplasm
CCIDAGO:0009986cell surface
CCIEAGO:0030141secretory granule
CCIEAGO:0045177apical part of cell
CCIDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome
MFIBAGO:0004252serine-type endopeptidase activity
MFIDAGO:0004252serine-type endopeptidase activity
MFTASGO:0004252serine-type endopeptidase activity
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFTASGO:0005515protein binding
MFIPIGO:0051219phosphoprotein binding

Gene expression in normal tissue: PLAT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLAT


DatabasePathway IDPathway Des.
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP1533Vitamin B12 Metabolism
wikipathwaysWP176Folate Metabolism
wikipathwaysWP272Blood Clotting Cascade
wikipathwaysWP3413NOTCH1 regulation of human endothelial cell calcification
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP3897Dengue-2 Interactions with Blood Clotting Cascade
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP558Complement and Coagulation Cascades
wikipathwaysWP615Senescence and Autophagy in Cancer
smpdbSMP00268Warfarin Action Pathway
smpdbSMP00269Acenocoumarol Action Pathway
smpdbSMP00270Dicumarol Action Pathway
smpdbSMP00271Phenprocoumon Action Pathway
smpdbSMP00272Enoxaparin Action Pathway
smpdbSMP00273Fondaparinux Action Pathway
smpdbSMP00274Heparin Action Pathway
smpdbSMP00275Ardeparin Action Pathway
smpdbSMP00276Argatroban Action Pathway
smpdbSMP00277Bivalirudin Action Pathway
smpdbSMP00278Lepirudin Action Pathway
smpdbSMP00279Ximelagatran Action Pathway
smpdbSMP00280Alteplase Action Pathway
smpdbSMP00281Anistreplase Action Pathway
smpdbSMP00282Streptokinase Action Pathway
smpdbSMP00283Tenecteplase Action Pathway
smpdbSMP00284Urokinase Action Pathway
smpdbSMP00285Reteplase Action Pathway
smpdbSMP00286Aminocaproic Acid Action Pathway
smpdbSMP00287Tranexamic Acid Action Pathway
smpdbSMP00288Aprotinin Action Pathway
smpdbSMP00586Coagulation
smpdbSMP00655Phenindione Action Pathway
smpdbSMP00656Dicoumarol Action Pathway
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidamb2_neutrophils_pathwayamb2 Integrin signaling
pidintegrin2_pathwayBeta2 integrin cell surface interactions
biocartafibrinolysispathwayfibrinolysis pathway
biocartakeratinocytepathwaykeratinocyte differentiation
biocartaplateletapppathwayplatelet amyloid precursor protein pathway
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-75205Dissolution of Fibrin Clot
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD5Tyrphostin AG 14781
iGMDRD202Curcumin5
iGMDRD251ML1626
iGMDRD267Oligomycin A6
iGMDRD872BRD71373
iGMDRD414MST-3123
iGMDRD367Ro 28-16753
iGMDRD286Nsc 6328396
iGMDRD42Vorinostat7
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib5
iGMDRD886Compound 1541A4
iGMDRD330BRD41325
iGMDRD486Tosedostat1
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD435BI-25366
iGMDRD187BRD98761
iGMDRD885Compound 1102
iGMDRD441TW 371
iGMDRD318PAC-15
iGMDRD506Fedratinib8
iGMDRD188Piperlongumine2
iGMDRD100Zebularine2
iGMDRD524ISX-92
iGMDRD420Leucascandrolide A5
iGMDRD554CHEMBL14341373
iGMDRD781Sirolimus8
iGMDRD144NSC953973
iGMDRD2PK-111953
iGMDRD152179324-69-73
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD394BX-7952

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLAT

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