PLAT
Summary: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| plasminogen activator, tissue type | MIM:173370 | Ensembl:ENSG00000104368 | HGNC:HGNC:9051 | PA33381 | 8p11.21 |
GO terms in PLAT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IBA | GO:0006508 | proteolysis |
| BP | TAS | GO:0006508 | proteolysis |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IBA | GO:0014909 | smooth muscle cell migration |
| BP | IEA | GO:0014909 | smooth muscle cell migration |
| BP | IBA | GO:0031639 | plasminogen activation |
| BP | IDA | GO:0031639 | plasminogen activation |
| BP | TAS | GO:0042730 | fibrinolysis |
| BP | IDA | GO:0045861 | negative regulation of proteolysis |
| BP | IBA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IEA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0030141 | secretory granule |
| CC | IEA | GO:0045177 | apical part of cell |
| CC | IDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IBA | GO:0004252 | serine-type endopeptidase activity |
| MF | IDA | GO:0004252 | serine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005515 | protein binding |
| MF | IPI | GO:0051219 | phosphoprotein binding |
Gene expression in normal tissue: PLAT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLAT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP272 | Blood Clotting Cascade |
| wikipathways | WP3413 | NOTCH1 regulation of human endothelial cell calcification |
| wikipathways | WP3896 | Dengue-2 Interactions with Complement and Coagulation Cascades |
| wikipathways | WP3897 | Dengue-2 Interactions with Blood Clotting Cascade |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP474 | Endochondral Ossification |
| wikipathways | WP558 | Complement and Coagulation Cascades |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| smpdb | SMP00268 | Warfarin Action Pathway |
| smpdb | SMP00269 | Acenocoumarol Action Pathway |
| smpdb | SMP00270 | Dicumarol Action Pathway |
| smpdb | SMP00271 | Phenprocoumon Action Pathway |
| smpdb | SMP00272 | Enoxaparin Action Pathway |
| smpdb | SMP00273 | Fondaparinux Action Pathway |
| smpdb | SMP00274 | Heparin Action Pathway |
| smpdb | SMP00275 | Ardeparin Action Pathway |
| smpdb | SMP00276 | Argatroban Action Pathway |
| smpdb | SMP00277 | Bivalirudin Action Pathway |
| smpdb | SMP00278 | Lepirudin Action Pathway |
| smpdb | SMP00279 | Ximelagatran Action Pathway |
| smpdb | SMP00280 | Alteplase Action Pathway |
| smpdb | SMP00281 | Anistreplase Action Pathway |
| smpdb | SMP00282 | Streptokinase Action Pathway |
| smpdb | SMP00283 | Tenecteplase Action Pathway |
| smpdb | SMP00284 | Urokinase Action Pathway |
| smpdb | SMP00285 | Reteplase Action Pathway |
| smpdb | SMP00286 | Aminocaproic Acid Action Pathway |
| smpdb | SMP00287 | Tranexamic Acid Action Pathway |
| smpdb | SMP00288 | Aprotinin Action Pathway |
| smpdb | SMP00586 | Coagulation |
| smpdb | SMP00655 | Phenindione Action Pathway |
| smpdb | SMP00656 | Dicoumarol Action Pathway |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | integrin2_pathway | Beta2 integrin cell surface interactions |
| biocarta | fibrinolysispathway | fibrinolysis pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | plateletapppathway | platelet amyloid precursor protein pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-75205 | Dissolution of Fibrin Clot |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD251 | ML162 | 6 |
| iGMDRD267 | Oligomycin A | 6 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD42 | Vorinostat | 7 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD330 | BRD4132 | 5 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD781 | Sirolimus | 8 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD2 | PK-11195 | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD394 | BX-795 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLAT
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.