TNFRSF11B
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 11b | MIM:602643 | Ensembl:ENSG00000164761 | HGNC:HGNC:11909 | PA36602 | 8q24.12 |
GO terms in TNFRSF11B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007584 | response to nutrient |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0032026 | response to magnesium ion |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0042489 | negative regulation of odontogenesis of dentin-containing tooth |
| BP | IEA | GO:0042493 | response to drug |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IEA | GO:0045779 | negative regulation of bone resorption |
| BP | IEA | GO:0046685 | response to arsenic-containing substance |
| MF | TAS | GO:0005125 | cytokine activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
Gene expression in normal tissue: TNFRSF11B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF11B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| wikipathways | WP12 | Osteoclast Signaling |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP322 | Osteoblast Signaling |
| wikipathways | WP727 | Monoamine Transport |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD150 | RITA | 4 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD356 | PNU-74654 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF11B
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