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FRK

Summary: The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
fyn related Src family tyrosine kinase	MIM:606573	Ensembl:ENSG00000111816	HGNC:HGNC:3955	PA28373	6q22.1

Gene Categories:

DRUGGABLE GENOME TYROSINE KINASE KINASE

GO terms in FRK

Term Type	Evidence Type	GO Term ID	GO Des.
MF	EXP	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IBA	GO:0005102	signaling receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	TAS	GO:0006468	protein phosphorylation
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	TAS	GO:0008285	negative regulation of cell proliferation
BP	IBA	GO:0030154	cell differentiation
BP	IBA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	IBA	GO:0042127	regulation of cell proliferation
BP	TAS	GO:0043312	neutrophil degranulation
BP	IBA	GO:0045087	innate immune response
CC	TAS	GO:0005576	extracellular region
CC	TAS	GO:0005622	intracellular
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
CC	TAS	GO:0035578	azurophil granule lumen
CC	TAS	GO:0035580	specific granule lumen
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: FRK

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FRK

Database	Pathway ID	Pathway Des.
netpath	Pathway_EGFR1	EGFR1
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-6798695	Neutrophil degranulation
reactome	R-HSA-6807070	PTEN Regulation
reactome	R-HSA-8948751	Regulation of PTEN stability and activity
reactome	R-HSA-9006925	Intracellular signaling by second messengers

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD466	Chaetocin	2
iGMDRD280	CYTOCHALASIN B	10
iGMDRD394	BX-795	1
iGMDRD375	GW-405833	3
iGMDRD634	SCHEMBL2608041	7
iGMDRD387	CHIR-99021	2
iGMDRD772	BRD4770	1
iGMDRD670	ML 210	1
iGMDRD427	ABT737	3
iGMDRD483	SCH-529074	2
iGMDRD484	Pluripotin	4
iGMDRD887	Compound 23 citrate	2
iGMDRD577	BIX01294	4
iGMDRD398	Sepantronium	5
iGMDRD780	PP-30	2
iGMDRD562	Navitoclax	3
iGMDRD60	Quinoclamine	2
iGMDRD524	ISX-9	1
iGMDRD138	PX 12	3
iGMDRD171	Pemetrexed	3
iGMDRD782	DC-45-A2	2
iGMDRD85	Ursolic acid	1
iGMDRD351	GW843682X	4
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD211	(1S,3R)-RSL3	1
iGMDRD177	Teniposide	2
iGMDRD123	Isoevodiamine	5
iGMDRD511	CHEMBL399379	1
iGMDRD154	NSC23766	3
iGMDRD84	Lovastatin acid	1
iGMDRD512	nutlin 3	2
iGMDRD584	VER 155008	2
iGMDRD150	RITA	3
iGMDRD424	Tamatinib	1
iGMDRD345	Compound 10b [PMID: 11504634]	4
iGMDRD523	Cyanoquinoline, 11	3
iGMDRD701	NVP-AUY922	2
iGMDRD414	MST-312	8
iGMDRD286	Nsc 632839	7
iGMDRD329	Merck60	3
iGMDRD505	Pevonedistat	1
iGMDRD246	NPC26	3
iGMDRD147	Prima-1	1
iGMDRD322	FK 866	1
iGMDRD103	SN-38	3
iGMDRD137	Indisulam	7
iGMDRD121	GMX1778	1
iGMDRD271	Brefeldin A	2
iGMDRD202	Curcumin	2
iGMDRD5	Tyrphostin AG 1478	6
iGMDRD289	Parthenolide	3
iGMDRD705	Nakiterpiosin	5
iGMDRD434	BMS-536924	2
iGMDRD481	Dactolisib	1
iGMDRD267	Oligomycin A	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FRK

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.