AGER

Summary: The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameadvanced glycosylation end-product specific receptor
OMIM IDMIM:600214
Ensembl IDEnsembl:ENSG00000204305
HGNC IDHGNC:HGNC:320
PHARMGKB IDPA24617
Map Location6p21.32

GO terms in AGER


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF NAS GO:0001540 amyloid-beta binding
MF TAS GO:0001540 amyloid-beta binding
MF TAS GO:0004888 transmembrane signaling receptor activity
MF TAS GO:0005044 scavenger receptor activity
MF IPI GO:0005515 protein binding
MF IEA GO:0008201 heparin binding
Showing 1 to 6 of 64 rows rows per page

Gene expression in normal tissue: AGER

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined25Metabolism1One carbon pool by folate1p53 pathway1ERK MAPK signaling1IGFR signaling1Apoptosis regulation1

Pathways in AGER


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
reactome R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
reactome R-HSA-166166 MyD88-independent TLR4 cascade
reactome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
reactome R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
Showing 1 to 6 of 35 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD193 Fqi1 3
iGMDRD61 Kinetin riboside 3
iGMDRD85 Ursolic acid 3
iGMDRD280 CYTOCHALASIN B 2
Showing 1 to 4 of 31 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGER

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.