AGER
Summary: The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| advanced glycosylation end-product specific receptor | MIM:600214 | Ensembl:ENSG00000204305 | HGNC:HGNC:320 | PA24617 | 6p21.32 |
GO terms in AGER
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0001540 | amyloid-beta binding |
| MF | TAS | GO:0001540 | amyloid-beta binding |
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | TAS | GO:0005044 | scavenger receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008201 | heparin binding |
| MF | IMP | GO:0038023 | signaling receptor activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0044548 | S100 protein binding |
| MF | NAS | GO:0050785 | advanced glycation end-product receptor activity |
| MF | IEA | GO:1904599 | advanced glycation end-product binding |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | NAS | GO:0009986 | cell surface |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0030054 | cell junction |
| CC | TAS | GO:0098794 | postsynapse |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0001914 | regulation of T cell mediated cytotoxicity |
| BP | IGI | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0006898 | receptor-mediated endocytosis |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IGI | GO:0007611 | learning or memory |
| BP | TAS | GO:0009611 | response to wounding |
| BP | IDA | GO:0010255 | glucose mediated signaling pathway |
| BP | IEA | GO:0014002 | astrocyte development |
| BP | IGI | GO:0031175 | neuron projection development |
| BP | IDA | GO:0032693 | negative regulation of interleukin-10 production |
| BP | IMP | GO:0032735 | positive regulation of interleukin-12 production |
| BP | IMP | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | IEA | GO:0043507 | positive regulation of JUN kinase activity |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IGI | GO:0046330 | positive regulation of JNK cascade |
| BP | TAS | GO:0048167 | regulation of synaptic plasticity |
| BP | IEA | GO:0050930 | induction of positive chemotaxis |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IGI | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051101 | regulation of DNA binding |
| BP | IGI | GO:0061890 | positive regulation of astrocyte activation |
| BP | IGI | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production |
| BP | IEA | GO:0072657 | protein localization to membrane |
| BP | IGI | GO:0090647 | modulation of age-related behavioral decline |
| BP | IGI | GO:0150003 | regulation of spontaneous synaptic transmission |
| BP | ISS | GO:1900271 | regulation of long-term synaptic potentiation |
| BP | IGI | GO:1900272 | negative regulation of long-term synaptic potentiation |
| BP | ISS | GO:1900272 | negative regulation of long-term synaptic potentiation |
| BP | IGI | GO:1900453 | negative regulation of long term synaptic depression |
| BP | ISS | GO:1900744 | regulation of p38MAPK cascade |
| BP | IGI | GO:1900745 | positive regulation of p38MAPK cascade |
| BP | NAS | GO:1901222 | regulation of NIK/NF-kappaB signaling |
| BP | IGI | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IGI | GO:1903980 | positive regulation of microglial cell activation |
| BP | IEA | GO:1904597 | negative regulation of connective tissue replacement involved in inflammatory response wound healing |
| BP | IEA | GO:1904604 | negative regulation of advanced glycation end-product receptor activity |
| BP | ISS | GO:1904645 | response to amyloid-beta |
| BP | TAS | GO:1904645 | response to amyloid-beta |
| BP | ISS | GO:1904646 | cellular response to amyloid-beta |
| BP | IDA | GO:2000514 | regulation of CD4-positive, alpha-beta T cell activation |
| BP | IMP | GO:2001200 | positive regulation of dendritic cell differentiation |
Gene expression in normal tissue: AGER
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGER
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-879415 | Advanced glycosylation endproduct receptor signaling |
| reactome | R-HSA-879415 | Advanced glycosylation endproduct receptor signaling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-933542 | TRAF6 mediated NF-kB activation |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| netpath | Pathway_RAGE | RAGE |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD405 | PIK-75 | 6 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD802 | 4-methylfasudil | 5 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD171 | Pemetrexed | 6 |
| iGMDRD705 | Nakiterpiosin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGER
CLASSFICATION
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