GRIN2B
Summary: This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamate ionotropic receptor NMDA type subunit 2B | MIM:138252 | Ensembl:ENSG00000273079 | HGNC:HGNC:4586 | PA28980 | 12p13.1 |
GO terms in GRIN2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005622 | intracellular |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0009986 | cell surface |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | IBA | GO:0017146 | NMDA selective glutamate receptor complex |
| CC | IDA | GO:0017146 | NMDA selective glutamate receptor complex |
| CC | TAS | GO:0017146 | NMDA selective glutamate receptor complex |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0043005 | neuron projection |
| CC | TAS | GO:0045211 | postsynaptic membrane |
| CC | ISS | GO:0097060 | synaptic membrane |
| CC | IBA | GO:0098839 | postsynaptic density membrane |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0007215 | glutamate receptor signaling pathway |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | NAS | GO:0007420 | brain development |
| BP | ISS | GO:0007611 | learning or memory |
| BP | IEA | GO:0019722 | calcium-mediated signaling |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | IDA | GO:0045471 | response to ethanol |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | NAS | GO:0048167 | regulation of synaptic plasticity |
| BP | ISS | GO:0051290 | protein heterotetramerization |
| BP | IBA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IBA | GO:0060291 | long-term synaptic potentiation |
| BP | IDA | GO:0097553 | calcium ion transmembrane import into cytosol |
| BP | IMP | GO:0097553 | calcium ion transmembrane import into cytosol |
| BP | NAS | GO:0098976 | excitatory chemical synaptic transmission |
| BP | ISS | GO:1901216 | positive regulation of neuron death |
| BP | ISS | GO:1902951 | negative regulation of dendritic spine maintenance |
| BP | ISS | GO:2001056 | positive regulation of cysteine-type endopeptidase activity |
| MF | IBA | GO:0004972 | NMDA glutamate receptor activity |
| MF | IDA | GO:0004972 | NMDA glutamate receptor activity |
| MF | ISS | GO:0004972 | NMDA glutamate receptor activity |
| MF | TAS | GO:0004972 | NMDA glutamate receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005234 | extracellularly glutamate-gated ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0016594 | glycine binding |
| MF | ISS | GO:0016595 | glutamate binding |
| MF | IDA | GO:0022849 | glutamate-gated calcium ion channel activity |
| MF | IMP | GO:0022849 | glutamate-gated calcium ion channel activity |
Gene expression in normal tissue: GRIN2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIN2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442729 | CREB phosphorylation through the activation of CaMKII |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6794361 | Neurexins and neuroligins |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-8849932 | Synaptic adhesion-like molecules |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05030 | Cocaine addiction - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | reelinpathway | Reelin signaling pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
| wikipathways | WP4223 | Ras Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD61 | Kinetin riboside | 9 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIN2B
CLASSFICATION
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