MEF2A
Summary: The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myocyte enhancer factor 2A | MIM:600660 | Ensembl:ENSG00000068305 | HGNC:HGNC:6993 | PA30731 | 15q26.3 |
GO terms in MEF2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IBA | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IBA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IPI | GO:0035035 | histone acetyltransferase binding |
| MF | IBA | GO:0042826 | histone deacetylase binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IPI | GO:0046332 | SMAD binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | ISS | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005829 | cytosol |
| BP | ISS | GO:0000002 | mitochondrial genome maintenance |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEP | GO:0007507 | heart development |
| BP | NAS | GO:0007517 | muscle organ development |
| BP | IDA | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IGI | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046326 | positive regulation of glucose import |
| BP | ISS | GO:0048311 | mitochondrion distribution |
| BP | ISS | GO:0048813 | dendrite morphogenesis |
| BP | TAS | GO:0051149 | positive regulation of muscle cell differentiation |
| BP | ISS | GO:0055005 | ventricular cardiac myofibril assembly |
| BP | ISS | GO:0061337 | cardiac conduction |
| BP | IMP | GO:0070375 | ERK5 cascade |
| BP | IDA | GO:0071277 | cellular response to calcium ion |
Gene expression in normal tissue: MEF2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MEF2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1991 | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | hdacpathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | mitrpathway | signal dependent regulation of myogenesis by corepressor mitr |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| biocarta | pgc1apathway | regulation of pgc-1a |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 6 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MEF2A
CLASSFICATION
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