CLTC
Summary: Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| clathrin heavy chain | MIM:118955 | Ensembl:ENSG00000141367 | HGNC:HGNC:2092 | PA26618 | 17q23.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in CLTC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | NAS | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0030506 | ankyrin binding |
| MF | IBA | GO:0031072 | heat shock protein binding |
| MF | IBA | GO:0032051 | clathrin light chain binding |
| MF | IPI | GO:0032051 | clathrin light chain binding |
| MF | IBA | GO:0042277 | peptide binding |
| MF | IBA | GO:0042802 | identical protein binding |
| MF | IBA | GO:0050750 | low-density lipoprotein particle receptor binding |
| MF | IPI | GO:0050750 | low-density lipoprotein particle receptor binding |
| MF | IBA | GO:0097718 | disordered domain specific binding |
| MF | IPI | GO:0097718 | disordered domain specific binding |
| MF | IPI | GO:1990381 | ubiquitin-specific protease binding |
| MF | IBA | GO:1990763 | arrestin family protein binding |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005768 | endosome |
| CC | IBA | GO:0005819 | spindle |
| CC | IDA | GO:0005819 | spindle |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | IMP | GO:0030118 | clathrin coat |
| CC | NAS | GO:0030118 | clathrin coat |
| CC | IEA | GO:0030130 | clathrin coat of trans-Golgi network vesicle |
| CC | IEA | GO:0030132 | clathrin coat of coated pit |
| CC | IDA | GO:0030136 | clathrin-coated vesicle |
| CC | IBA | GO:0030315 | T-tubule |
| CC | TAS | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| CC | TAS | GO:0032588 | trans-Golgi network membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | TAS | GO:0036020 | endolysosome membrane |
| CC | IEA | GO:0042470 | melanosome |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IBA | GO:0045334 | clathrin-coated endocytic vesicle |
| CC | NAS | GO:0045334 | clathrin-coated endocytic vesicle |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IBA | GO:0071439 | clathrin complex |
| CC | IDA | GO:0071439 | clathrin complex |
| CC | IDA | GO:0072686 | mitotic spindle |
| CC | HDA | GO:1903561 | extracellular vesicle |
| CC | IDA | GO:1990498 | mitotic spindle microtubule |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IMP | GO:0000278 | mitotic cell cycle |
| BP | HDA | GO:0001649 | osteoblast differentiation |
| BP | NAS | GO:0006886 | intracellular protein transport |
| BP | IBA | GO:0006898 | receptor-mediated endocytosis |
| BP | IMP | GO:0006898 | receptor-mediated endocytosis |
| BP | IEA | GO:0006914 | autophagy |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | IMP | GO:0031623 | receptor internalization |
| BP | TAS | GO:0032802 | low-density lipoprotein particle receptor catabolic process |
| BP | IBA | GO:0033572 | transferrin transport |
| BP | IMP | GO:0033572 | transferrin transport |
| BP | TAS | GO:0034383 | low-density lipoprotein particle clearance |
| BP | IMP | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | IMP | GO:0045056 | transcytosis |
| BP | IBA | GO:0048268 | clathrin coat assembly |
| BP | IMP | GO:0048268 | clathrin coat assembly |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | IBA | GO:0060236 | regulation of mitotic spindle organization |
| BP | IMP | GO:0060236 | regulation of mitotic spindle organization |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IMP | GO:0072583 | clathrin-dependent endocytosis |
| BP | IDA | GO:1900126 | negative regulation of hyaluronan biosynthetic process |
| BP | IMP | GO:1900126 | negative regulation of hyaluronan biosynthetic process |
| BP | IMP | GO:1903077 | negative regulation of protein localization to plasma membrane |
Gene expression in normal tissue: CLTC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLTC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-157858 | Gap junction trafficking and regulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-190828 | Gap junction trafficking |
| reactome | R-HSA-190873 | Gap junction degradation |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-196025 | Formation of annular gap junctions |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-432720 | Lysosome Vesicle Biogenesis |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-5099900 | WNT5A-dependent internalization of FZD4 |
| reactome | R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8866427 | VLDLR internalisation and degradation |
| reactome | R-HSA-8964038 | LDL clearance |
| reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | faspathway | FAS (CD95) signaling pathway |
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| wikipathways | WP2267 | Synaptic Vesicle Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3896 | Dengue-2 Interactions with Complement and Coagulation Cascades |
| wikipathways | WP558 | Complement and Coagulation Cascades |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD280 | CYTOCHALASIN B | 7 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD639 | YK 4-279 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD158 | NSC141540 | 7 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 6 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD351 | GW843682X | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLTC
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.