PPP3CB
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 3 catalytic subunit beta | MIM:114106 | Ensembl:ENSG00000107758 | HGNC:HGNC:9315 | PA33679 | 10q22.2 |
GO terms in PPP3CB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | NAS | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0008144 | drug binding |
| MF | IDA | GO:0019899 | enzyme binding |
| MF | IDA | GO:0030346 | protein phosphatase 2B binding |
| MF | IBA | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| MF | IDA | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| MF | ISS | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| MF | TAS | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| MF | IPI | GO:0046983 | protein dimerization activity |
| BP | IEA | GO:0001915 | negative regulation of T cell mediated cytotoxicity |
| BP | IEA | GO:0001946 | lymphangiogenesis |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | ISS | GO:0006470 | protein dephosphorylation |
| BP | NAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | IEA | GO:0007507 | heart development |
| BP | TAS | GO:0007612 | learning |
| BP | TAS | GO:0007613 | memory |
| BP | TAS | GO:0016311 | dephosphorylation |
| BP | ISS | GO:0017156 | calcium ion regulated exocytosis |
| BP | IEA | GO:0030217 | T cell differentiation |
| BP | IEA | GO:0031987 | locomotion involved in locomotory behavior |
| BP | IDA | GO:0033173 | calcineurin-NFAT signaling cascade |
| BP | IEA | GO:0034097 | response to cytokine |
| BP | IEP | GO:0035176 | social behavior |
| BP | IDA | GO:0035690 | cellular response to drug |
| BP | ISS | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | NAS | GO:0042098 | T cell proliferation |
| BP | TAS | GO:0042110 | T cell activation |
| BP | IEA | GO:0043029 | T cell homeostasis |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0048167 | regulation of synaptic plasticity |
| BP | TAS | GO:0048675 | axon extension |
| BP | ISS | GO:0050796 | regulation of insulin secretion |
| BP | IBA | GO:0097720 | calcineurin-mediated signaling |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005955 | calcineurin complex |
| CC | IDA | GO:0005955 | calcineurin complex |
| CC | IEA | GO:0030018 | Z disc |
| CC | IEA | GO:0030315 | T-tubule |
Gene expression in normal tissue: PPP3CB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP3CB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-180024 | DARPP-32 events |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-2025928 | Calcineurin activates NFAT |
| reactome | R-HSA-2025928 | Calcineurin activates NFAT |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-9010642 | ROBO receptors bind AKAP5 |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | calcineurinpathway | effects of calcineurin in keratinocyte differentiation |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | ndkdynaminpathway | endocytotic role of ndk phosphins and dynamin |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | pgc1apathway | regulation of pgc-1a |
| biocarta | tcrpathway | t cell receptor signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 5 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD670 | ML 210 | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 4 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD341 | Triacsin c | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP3CB
CLASSFICATION
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