ABI1


Summary: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
abl interactor 1MIM:603050Ensembl:ENSG00000136754HGNC:HGNC:11320PA3614410p12.1

Gene Categories:

TYROSINE KINASEKINASE

GO terms in ABI1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFTASGO:0008092cytoskeletal protein binding
MFIPIGO:0017124SH3 domain binding
MFIEAGO:0030296protein tyrosine kinase activator activity
MFIDAGO:0044877protein-containing complex binding
MFHDAGO:0045296cadherin binding
BPIEAGO:0001756somitogenesis
BPTASGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPNASGO:0008154actin polymerization or depolymerization
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0016032viral process
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0035855megakaryocyte development
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEAGO:0048813dendrite morphogenesis
BPIEAGO:0061098positive regulation of protein tyrosine kinase activity
BPIEAGO:0072673lamellipodium morphogenesis
CCIDAGO:0005622intracellular
CCIEAGO:0005634nucleus
CCTASGO:0005783endoplasmic reticulum
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCIEAGO:0014069postsynaptic density
CCIDAGO:0030027lamellipodium
CCIEAGO:0030054cell junction
CCIEAGO:0030426growth cone
CCIDAGO:0031209SCAR complex
CCIDAGO:0032433filopodium tip
CCIEAGO:0045211postsynaptic membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ABI1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABI1


DatabasePathway IDPathway Des.
netpathPathway_EGFR1EGFR1
pidecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
piderbb1_downstream_pathwayErbB1 downstream signaling
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidrac1_pathwayRAC1 signaling pathway
pidrac1_reg_pathwayRegulation of RAC1 activity
wikipathwaysWP437EGF-EGFR Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD356PNU-746543
iGMDRD23Gossypol2
iGMDRD300Tozasertib3
iGMDRD60Quinoclamine2
iGMDRD506Fedratinib3
iGMDRD329Merck603
iGMDRD398Sepantronium3
iGMDRD871BRD63682
iGMDRD100Zebularine6
iGMDRD74Idarubicin2
iGMDRD137Indisulam2
iGMDRD280CYTOCHALASIN B6
iGMDRD123Isoevodiamine2
iGMDRD150RITA2
iGMDRD144NSC953972
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD126Tipifarnib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABI1

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