ABI1
Summary: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| abl interactor 1 | MIM:603050 | Ensembl:ENSG00000136754 | HGNC:HGNC:11320 | PA36144 | 10p12.1 |
GO terms in ABI1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008092 | cytoskeletal protein binding |
| MF | IPI | GO:0017124 | SH3 domain binding |
| MF | IEA | GO:0030296 | protein tyrosine kinase activator activity |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | IEA | GO:0001756 | somitogenesis |
| BP | TAS | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | NAS | GO:0008154 | actin polymerization or depolymerization |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0035855 | megakaryocyte development |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0048813 | dendrite morphogenesis |
| BP | IEA | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | IEA | GO:0072673 | lamellipodium morphogenesis |
| CC | IDA | GO:0005622 | intracellular |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030426 | growth cone |
| CC | IDA | GO:0031209 | SCAR complex |
| CC | IDA | GO:0032433 | filopodium tip |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ABI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABI1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD126 | Tipifarnib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABI1
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