MAPK3
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601795 Ensembl IDEnsembl:ENSG00000102882 HGNC IDHGNC:HGNC:6877 PHARMGKB IDPA30622 Map Location16p11.2 | |||||
GO terms in MAPK3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001784 | phosphotyrosine residue binding |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004707 | MAP kinase activity |
| MF | IDA | GO:0004707 | MAP kinase activity |
| MF | NAS | GO:0004707 | MAP kinase activity |
| MF | TAS | GO:0004707 | MAP kinase activity |
Gene expression in normal tissue: MAPK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPK3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | alk1pathway | ALK1 signaling events |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | arf6downstreampathway | Arf6 downstream pathway |
| pid | atf2_pathway | ATF-2 transcription factor network |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPK3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.