MAPK3
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase 3 | MIM:601795 | Ensembl:ENSG00000102882 | HGNC:HGNC:6877 | PA30622 | 16p11.2 |
GO terms in MAPK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001784 | phosphotyrosine residue binding |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004707 | MAP kinase activity |
| MF | IDA | GO:0004707 | MAP kinase activity |
| MF | NAS | GO:0004707 | MAP kinase activity |
| MF | TAS | GO:0004707 | MAP kinase activity |
| MF | IEA | GO:0004708 | MAP kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IPI | GO:0019902 | phosphatase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0097110 | scaffold protein binding |
| BP | NAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0002741 | positive regulation of cytokine secretion involved in immune response |
| BP | TAS | GO:0006361 | transcription initiation from RNA polymerase I promoter |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006975 | DNA damage induced protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010759 | positive regulation of macrophage chemotaxis |
| BP | TAS | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0016310 | phosphorylation |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0019233 | sensory perception of pain |
| BP | IEA | GO:0019369 | arachidonic acid metabolic process |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0030278 | regulation of ossification |
| BP | IMP | GO:0030509 | BMP signaling pathway |
| BP | IEA | GO:0030641 | regulation of cellular pH |
| BP | IEA | GO:0030878 | thyroid gland development |
| BP | IMP | GO:0031281 | positive regulation of cyclase activity |
| BP | IEA | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IMP | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | TAS | GO:0032872 | regulation of stress-activated MAPK cascade |
| BP | IMP | GO:0033129 | positive regulation of histone phosphorylation |
| BP | IDA | GO:0034198 | cellular response to amino acid starvation |
| BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
| BP | IMP | GO:0035066 | positive regulation of histone acetylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IEA | GO:0042473 | outer ear morphogenesis |
| BP | IEA | GO:0043330 | response to exogenous dsRNA |
| BP | IEA | GO:0045727 | positive regulation of translation |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048538 | thymus development |
| BP | TAS | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051216 | cartilage development |
| BP | IDA | GO:0051403 | stress-activated MAPK cascade |
| BP | TAS | GO:0051493 | regulation of cytoskeleton organization |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| BP | IEA | GO:0060020 | Bergmann glial cell differentiation |
| BP | IEA | GO:0060324 | face development |
| BP | IEA | GO:0060425 | lung morphogenesis |
| BP | IEA | GO:0060440 | trachea formation |
| BP | IEA | GO:0061308 | cardiac neural crest cell development involved in heart development |
| BP | IEA | GO:0065003 | protein-containing complex assembly |
| BP | IEA | GO:0070371 | ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IDA | GO:0070849 | response to epidermal growth factor |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IMP | GO:0071276 | cellular response to cadmium ion |
| BP | IBA | GO:0071310 | cellular response to organic substance |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | TAS | GO:0072584 | caveolin-mediated endocytosis |
| BP | TAS | GO:0090170 | regulation of Golgi inheritance |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IMP | GO:1903351 | cellular response to dopamine |
| BP | IMP | GO:1904355 | positive regulation of telomere capping |
| BP | IEA | GO:1904417 | positive regulation of xenophagy |
| BP | IEA | GO:1905050 | positive regulation of metallopeptidase activity |
| BP | TAS | GO:2000641 | regulation of early endosome to late endosome transport |
| BP | IEA | GO:2000657 | negative regulation of apolipoprotein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005769 | early endosome |
| CC | TAS | GO:0005770 | late endosome |
| CC | TAS | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005901 | caveola |
| CC | TAS | GO:0005901 | caveola |
| CC | TAS | GO:0005925 | focal adhesion |
| CC | IEA | GO:0031143 | pseudopodium |
| CC | IEA | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: MAPK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | alk1pathway | ALK1 signaling events |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | arf6downstreampathway | Arf6 downstream pathway |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | endothelinpathway | Endothelins |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | s1p_s1p3_pathway | S1P3 pathway |
| pid | s1p_s1p4_pathway | S1P4 pathway |
| pid | smad2_3pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | tcrraspathway | Ras signaling in the CD4+ TCR pathway |
| pid | telomerasepathway | Regulation of Telomerase |
| pid | trail_pathway | TRAIL signaling pathway |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165110622 | Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics |
| pharmgkb | PA165959425 | Pathway_PA165959425 |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
| pharmgkb | PA2023 | ACE Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1434 | Osteopontin Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2112 | IL17 signaling pathway |
| wikipathways | WP22 | IL-9 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2526 | PDGF Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP26 | Signal Transduction of S1P Receptor |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP2868 | TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3879 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP732 | Serotonin Receptor 2 and ELK-SRF-GATA4 signaling |
| wikipathways | WP734 | Serotonin Receptor 4-6-7 and NR3C Signaling |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_FSH | FSH |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_ID | ID |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_IL9 | IL9 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Notch | Notch |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSH | TSH |
| netpath | Pathway_TSLP | TSLP |
| netpath | Pathway_TWEAK | TWEAK |
| humancyc | PWY66-14 | MAP kinase cascade |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-202670 | ERKs are inactivated |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450341 | Activation of the AP-1 family of transcription factors |
| reactome | R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5674499 | Negative feedback regulation of MAPK pathway |
| reactome | R-HSA-5675221 | Negative regulation of MAPK pathway |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73728 | RNA Polymerase I Promoter Opening |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74749 | Signal attenuation |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-879415 | Advanced glycosylation endproduct receptor signaling |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8940973 | RUNX2 regulates osteoblast differentiation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | cdk5pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | dsppathway | regulation of map kinase pathways through dual specificity phosphatases |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | melanocytepathway | melanocyte development and pigmentation pathway |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | nkcellspathway | ras-independent pathway in nk cell-mediated cytotoxicity |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | sam68pathway | regulation of splicing through sam68 |
| biocarta | sppapathway | aspirin blocks signaling pathway involved in platelet activation |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| biocarta | stat3pathway | stat3 signaling pathway |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tgfbpathway | tgf beta signaling pathway |
| biocarta | tpopathway | tpo signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD103 | SN-38 | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD481 | Dactolisib | 4 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD652 | UNC0638 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD359 | OSW-1 | 2 |
| iGMDRD945 | ML214 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPK3
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.