FOS
Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Fos proto-oncogene, AP-1 transcription factor subunit | MIM:164810 | Ensembl:ENSG00000170345 | HGNC:HGNC:3796 | PA28212 | 14q24.3 |
GO terms in FOS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001661 | conditioned taste aversion |
| BP | TAS | GO:0006306 | DNA methylation |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | IDA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0009409 | response to cold |
| BP | IEA | GO:0009416 | response to light stimulus |
| BP | IEA | GO:0009629 | response to gravity |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030431 | sleep |
| BP | IEA | GO:0031668 | cellular response to extracellular stimulus |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IEA | GO:0032870 | cellular response to hormone stimulus |
| BP | IDA | GO:0034614 | cellular response to reactive oxygen species |
| BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
| BP | IEA | GO:0035902 | response to immobilization stress |
| BP | IEA | GO:0035914 | skeletal muscle cell differentiation |
| BP | IEA | GO:0035994 | response to muscle stretch |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IEA | GO:0045672 | positive regulation of osteoclast differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051412 | response to corticosterone |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | IDA | GO:0060395 | SMAD protein signal transduction |
| BP | IMP | GO:0071276 | cellular response to cadmium ion |
| BP | IEA | GO:0071277 | cellular response to calcium ion |
| BP | ISS | GO:1901216 | positive regulation of neuron death |
| BP | ISS | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| CC | IMP | GO:0032993 | protein-DNA complex |
| CC | IDA | GO:0035976 | transcription factor AP-1 complex |
| CC | IMP | GO:0035976 | transcription factor AP-1 complex |
| CC | IEA | GO:0043005 | neuron projection |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IMP | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IMP | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0070412 | R-SMAD binding |
Gene expression in normal tissue: FOS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450341 | Activation of the AP-1 family of transcription factors |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | ccr5pathway | pertussis toxin-insensitive ccr5 signaling in macrophage |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | etspathway | mets affect on macrophage differentiation |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il3pathway | il 3 signaling pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | ranklpathway | bone remodeling |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | tsp1pathway | tsp-1 induced apoptosis in microvascular endothelial cell |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | endothelinpathway | Endothelins |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hnf3apathway | FOXA1 transcription factor network |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| pid | tcrraspathway | Ras signaling in the CD4+ TCR pathway |
| pid | telomerasepathway | Regulation of Telomerase |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP28 | Selenium Metabolism and Selenoproteins |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3944 | Serotonin and anxiety-related events |
| wikipathways | WP3947 | Serotonin and anxiety |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP408 | Oxidative Stress |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP712 | Estrogen signaling pathway |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD25 | 138402-11-6 | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD405 | PIK-75 | 5 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD150 | RITA | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD466 | Chaetocin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOS
CLASSFICATION
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