FOS

Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameFos proto-oncogene, AP-1 transcription factor subunit
OMIM IDMIM:164810
Ensembl IDEnsembl:ENSG00000170345
HGNC IDHGNC:HGNC:3796
PHARMGKB IDPA28212
Map Location14q24.3

GO terms in FOS


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001661 conditioned taste aversion
BP TAS GO:0006306 DNA methylation
BP IBA GO:0006357 regulation of transcription by RNA polymerase II
BP TAS GO:0006357 regulation of transcription by RNA polymerase II
BP IEA GO:0006366 transcription by RNA polymerase II
BP TAS GO:0006954 inflammatory response
Showing 1 to 6 of 68 rows rows per page

Gene expression in normal tissue: FOS

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 31BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 42

Gene-drug pathway distribution

undefined24Purine metabolism1One carbon pool by folate1Adrenergic signaling in cardiomyocytes1

Pathways in FOS


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
reactome R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
reactome R-HSA-166166 MyD88-independent TLR4 cascade
reactome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
Showing 1 to 6 of 183 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 2
iGMDRD137 Indisulam 5
iGMDRD415 LE-135 3
iGMDRD171 Pemetrexed 2
Showing 1 to 4 of 27 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOS

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.