MYH1
Summary: Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin heavy chain 1 | MIM:160730 | Ensembl:ENSG00000109061 | HGNC:HGNC:7567 | PA31365 | 17p13.1 |
GO terms in MYH1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0051015 | actin filament binding |
| BP | IEA | GO:0006936 | muscle contraction |
| BP | IEA | GO:0007018 | microtubule-based movement |
| CC | IDA | GO:0005859 | muscle myosin complex |
| CC | IEA | GO:0014704 | intercalated disc |
| CC | IEA | GO:0031672 | A band |
| CC | IEA | GO:0032982 | myosin filament |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
Gene expression in normal tissue: MYH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD229 | B02 | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD237 | ABT-751 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYH1
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