CTSL
Summary: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cathepsin L | MIM:116880 | Ensembl:ENSG00000135047 | HGNC:HGNC:2537 | PA162382890 | 9q21.33 |
GO terms in CTSL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005634 | nucleus |
| CC | IBA | GO:0005764 | lysosome |
| CC | IDA | GO:0005764 | lysosome |
| CC | TAS | GO:0036021 | endolysosome lumen |
| CC | TAS | GO:0043202 | lysosomal lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEP | GO:0002250 | adaptive immune response |
| BP | IDA | GO:0006508 | proteolysis |
| BP | TAS | GO:0019882 | antigen processing and presentation |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | IDA | GO:0030574 | collagen catabolic process |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | TAS | GO:0045616 | regulation of keratinocyte differentiation |
| BP | IBA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | IDA | GO:0051603 | proteolysis involved in cellular protein catabolic process |
| BP | NAS | GO:0071888 | macrophage apoptotic process |
| BP | IEP | GO:0097067 | cellular response to thyroid hormone stimulus |
| MF | IPI | GO:0001968 | fibronectin binding |
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005518 | collagen binding |
| MF | IDA | GO:0008234 | cysteine-type peptidase activity |
| MF | IDA | GO:0042393 | histone binding |
| MF | IPI | GO:0043394 | proteoglycan binding |
| MF | IPI | GO:0097655 | serpin family protein binding |
Gene expression in normal tissue: CTSL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTSL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236977 | Endosomal/Vacuolar pathway |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD505 | Pevonedistat | 8 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD150 | RITA | 6 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD394 | BX-795 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTSL
CLASSFICATION
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