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CTSL

Summary: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecathepsin L OMIM IDMIM:116880 Ensembl IDEnsembl:ENSG00000135047 HGNC IDHGNC:HGNC:2537 PHARMGKB IDPA162382890 Map Location9q21.33

Gene Categories:

PROTEASE DRUGGABLE GENOME

GO terms in CTSL

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	NAS	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	IDA	GO:0005615	extracellular space
CC	TAS	GO:0005634	nucleus
CC	IBA	GO:0005764	lysosome

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Gene expression in normal tissue: CTSL

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTSL

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1236975	Antigen processing-Cross presentation
reactome	R-HSA-1236977	Endosomal/Vacuolar pathway
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1442490	Collagen degradation
reactome	R-HSA-1474228	Degradation of the extracellular matrix

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD5	Tyrphostin AG 1478	4
iGMDRD121	GMX1778	3
iGMDRD137	Indisulam	5
iGMDRD289	Parthenolide	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTSL

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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