CEBPA
Summary: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CCAAT enhancer binding protein alpha | MIM:116897 | Ensembl:ENSG00000245848 | HGNC:HGNC:1833 | PA26376 | 19q13.11 |
GO terms in CEBPA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IMP | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | NAS | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | ISS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IMP | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | IEA | GO:0000050 | urea cycle |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0001889 | liver development |
| BP | IEA | GO:0001892 | embryonic placenta development |
| BP | TAS | GO:0006091 | generation of precursor metabolites and energy |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007005 | mitochondrion organization |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0008203 | cholesterol metabolic process |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | NAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | NAS | GO:0030099 | myeloid cell differentiation |
| BP | IEA | GO:0030225 | macrophage differentiation |
| BP | ISS | GO:0030324 | lung development |
| BP | ISS | GO:0030851 | granulocyte differentiation |
| BP | TAS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | IEA | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IEA | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | TAS | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045945 | positive regulation of transcription by RNA polymerase III |
| BP | IEA | GO:0048469 | cell maturation |
| BP | IEA | GO:0048839 | inner ear development |
| BP | IEA | GO:0050872 | white fat cell differentiation |
| BP | IEA | GO:0050873 | brown fat cell differentiation |
| BP | ISS | GO:0055088 | lipid homeostasis |
| BP | IEA | GO:0071285 | cellular response to lithium ion |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
Gene expression in normal tissue: CEBPA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CEBPA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL4 | IL4 |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2751 | Transcriptional regulation of white adipocyte differentiation |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP4211 | Transcriptional cascade regulating adipogenesis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD375 | GW-405833 | 4 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD177 | Teniposide | 7 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 8 |
| iGMDRD162 | All-trans Retinoic Acid | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD791 | OICR-9429 | 1 |
| iGMDRD79 | Gemcitabine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CEBPA
CLASSFICATION
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